Literature DB >> 12232501

Cellular longevity: role of apoptosis and replicative senescence.

Ronan T Bree1, Catherine Stenson-Cox, Maura Grealy, Lucy Byrnes, Adrienne M Gorman, Afshin Samali.   

Abstract

Cellular longevity refers to the lifespan of an individual cell. Normal cells have a finite lifespan and typically die by undergoing apoptosis, or enter into a state of irreversible growth arrest, termed replicative senescence, at the end of that lifespan. The lifespan of a cell is a balance between pro-survival/anti-apoptotic and pro-apoptotic death-promoting factors. The role of heat shock proteins, Bcl-2 family members, antioxidant molecules, and telomere length and telomerase activity in the regulation of apoptosis and replicative senescence, will be discussed.

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Year:  2002        PMID： 12232501     DOI： 10.1023/a:1016299812327

Source DB:  PubMed          Journal:  Biogerontology        ISSN： 1389-5729            Impact factor:   4.277


  14 in total

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Review 2.  DNA double-strand breaks: a potential causative factor for mammalian aging?

Authors:  Han Li; James R Mitchell; Paul Hasty
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3.  Cellular stress responses: cell survival and cell death.

Authors:  Simone Fulda; Adrienne M Gorman; Osamu Hori; Afshin Samali
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4.  Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis.

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5.  Altered expression of genes associated with telomere maintenance and cell function of human vascular endothelial cell at elevated temperature.

Authors:  Toyoki Maeda; Jing-Zhi Guan; Masamichi Koyanagi; Naoki Makino
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Review 6.  Are there roles for brain cell senescence in aging and neurodegenerative disorders?

Authors:  Florence C C Tan; Emmette R Hutchison; Erez Eitan; Mark P Mattson
Journal:  Biogerontology       Date:  2014-10-11       Impact factor: 4.277

7.  Expression of X-linked inhibitor of apoptosis protein in neoplastic thyroid disorder.

Authors:  Ji Hye Yim; Jong Ho Yoon; Sun A Kim; Won Gu Kim; Min Ji Jeon; Ji Min Han; Tae Yon Sung; Tae Yong Kim; Won Bae Kim; Suck Joon Hong; Young Kee Shong; Gyungyub Gong
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8.  Cryptochromes and Hormone Signal Transduction under Near-Zero Magnetic Fields: New Clues to Magnetic Field Effects in a Rice Planthopper.

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Journal:  PLoS One       Date:  2015-07-14       Impact factor: 3.240

Review 9.  Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies-A review.

Authors:  Sandeep Nayar; Prokar Dasgupta; Christine Galustian
Journal:  Oncoimmunology       Date:  2015-03-19       Impact factor: 8.110

10.  Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence.

Authors:  Sijia Cao; Gregory B Walker; Xuefeng Wang; Jing Z Cui; Joanne A Matsubara
Journal:  Mol Vis       Date:  2013-03-21       Impact factor: 2.367
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