OBJECTIVE: Summarizing the many discovered mouse and human quantitative trait loci (QTL) for high density lipoprotein (HDL) cholesterol (HDL-C) levels is important for guiding future research on the genetic regulation of HDL concentrations and for finding gene targets for upregulating HDL levels in mice and humans. METHODS AND RESULTS: We summarized the 27 QTL and candidate genes associated with HDL-C concentrations in mice and plotted them on a mouse chromosome map. We also summarized the 22 human QTL for HDL-C levels and compared them with those of the mouse by comparative genomics. At least part of the mouse homologies for 18 of the 22 human HDL-C QTL were within the murine HDL-C QTL. CONCLUSIONS: Murine QTL for HDL-C levels may predict their homologous location in humans, and their underlying genes may be appropriate genes to test in humans.
OBJECTIVE: Summarizing the many discovered mouse and human quantitative trait loci (QTL) for high density lipoprotein (HDL) cholesterol (HDL-C) levels is important for guiding future research on the genetic regulation of HDL concentrations and for finding gene targets for upregulating HDL levels in mice and humans. METHODS AND RESULTS: We summarized the 27 QTL and candidate genes associated with HDL-C concentrations in mice and plotted them on a mouse chromosome map. We also summarized the 22 human QTL for HDL-C levels and compared them with those of the mouse by comparative genomics. At least part of the mouse homologies for 18 of the 22 human HDL-C QTL were within the murine HDL-C QTL. CONCLUSIONS:Murine QTL for HDL-C levels may predict their homologous location in humans, and their underlying genes may be appropriate genes to test in humans.
Authors: Xiaosong Wang; Isabelle Le Roy; Edwige Nicodeme; Renhua Li; Richard Wagner; Christina Petros; Gary A Churchill; Stephen Harris; Ariel Darvasi; Jorge Kirilovsky; Pierre L Roubertoux; Beverly Paigen Journal: Genome Res Date: 2003-06-12 Impact factor: 9.043
Authors: Henning Wittenburg; Malcolm A Lyons; Renhua Li; Ulrike Kurtz; Joachim Mössner; Gary A Churchill; Martin C Carey; Beverly Paigen Journal: Mamm Genome Date: 2005-07 Impact factor: 2.957
Authors: David A Blizard; Arimantas Lionikas; David J Vandenbergh; Terrie Vasilopoulos; Glenn S Gerhard; James W Griffith; Laura C Klein; Joseph T Stout; Holly A Mack; Joan M Lakoski; Lars Larsson; Jeanne M Spicer; George P Vogler; Gerald E McClearn Journal: Physiol Genomics Date: 2008-12-09 Impact factor: 3.107
Authors: Rong Yang; Lin Li; Sara Bretschger Seidelmann; Gong-Qing Shen; Sonia Sharma; Shaoqi Rao; Kalil G Abdullah; Kenneth G Mackinlay; Robert C Elston; Qiuyun Chen; Eric J Topol; Qing Kenneth Wang Journal: J Lipid Res Date: 2010-01-14 Impact factor: 5.922
Authors: Alessandra C L Cervino; Ariel Darvasi; Mohammad Fallahi; Christopher C Mader; Nicholas F Tsinoremas Journal: Genetics Date: 2006-10-08 Impact factor: 4.562
Authors: Gudrun A Brockmann; Ersin Karatayli; Christina Neuschl; Ioannis M Stylianou; Soner Aksu; Antje Ludwig; Ulla Renne; Chris S Haley; Sara Knott Journal: Mamm Genome Date: 2007-11-08 Impact factor: 2.957