| Literature DB >> 12231360 |
Edna Cukierman1, Roumen Pankov, Kenneth M Yamada.
Abstract
Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.Entities:
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Year: 2002 PMID: 12231360 DOI: 10.1016/s0955-0674(02)00364-2
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN: 0955-0674 Impact factor: 8.382