Literature DB >> 12231259

Testosterone regulates BCL-2 immunoreactivity in a sexually dimorphic motor pool of adult rats.

Susan L Zup1, Nancy G Forger.   

Abstract

Bcl-2 and Bax immunoreactivity were examined in the spinal nucleus of the bulbocavernosus (SNB), an androgen-sensitive motor pool of adult rats. Castration reduced Bcl-2 immunoreactivity and testosterone treatment of castrates prevented this decline. Hormone manipulations did not affect Bcl-2 or Bax staining in the retrodorsolateral nucleus (RDLN), a relatively androgen-insensitive nucleus at the same spinal level. Changes in Bcl-2 expression may underlie the hormonal control of cell death and/or neural plasticity in SNB motoneurons.

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Year:  2002        PMID： 12231259     DOI： 10.1016/s0006-8993(02)03190-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Rapid seasonal-like regression of the adult avian song control system.

Authors:  Christopher K Thompson; George E Bentley; Eliot A Brenowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-17       Impact factor: 11.205

Review 2.  Sexual differentiation of the brain and ADHD: what is a sex difference in prevalence telling us?

Authors:  Jaylyn Waddell; Margaret M McCarthy
Journal:  Curr Top Behav Neurosci       Date:  2012

3.  Neuroprotective effects of testosterone in a naturally occurring model of neurodegeneration in the adult avian song control system.

Authors:  Christopher K Thompson; Eliot A Brenowitz
Journal:  J Comp Neurol       Date:  2010-12-01       Impact factor: 3.215

4.  Deletion of Bax eliminates sex differences in the mouse forebrain.

Authors:  Nancy G Forger; Greta J Rosen; Elizabeth M Waters; Dena Jacob; Richard B Simerly; Geert J de Vries
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-01       Impact factor: 11.205

5.  Caspase inhibitor infusion protects an avian song control circuit from seasonal-like neurodegeneration.

Authors:  Christopher K Thompson; Eliot A Brenowitz
Journal:  J Neurosci       Date:  2008-07-09       Impact factor: 6.167

6.  Androgenic, but not estrogenic, protection of motoneurons from somal and dendritic atrophy induced by the death of neighboring motoneurons.

Authors:  Keith N Fargo; Dale R Sengelaub
Journal:  Dev Neurobiol       Date:  2007-07       Impact factor: 3.964

7.  Overexpression of bcl-2 reduces sex differences in neuron number in the brain and spinal cord.

Authors:  Susan L Zup; Heather Carrier; Elizabeth M Waters; Abigail Tabor; Lynn Bengston; Greta J Rosen; Richard B Simerly; Nancy G Forger
Journal:  J Neurosci       Date:  2003-03-15       Impact factor: 6.167

8.  Nanoparticles of Costus speciosus Ameliorate Diabetes-Induced Structural Changes in Rat Prostate through Mediating the Pro-Inflammatory Cytokines IL 6, IL1β and TNF-α.

Authors:  Duaa Bakhshwin; Khadija Abdul Jalil Faddladdeen; Soad Shaker Ali; Samar Mohammed Alsaggaf; Nasra Naeim Ayuob
Journal:  Molecules       Date:  2022-02-02       Impact factor: 4.411
  8 in total

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