| Literature DB >> 12231216 |
Roberto Dominici1, Giulia Malferrari, Claudio Mariani, Luigi Grimaldi, Ida Biunno.
Abstract
Several studies have described polymorphisms in the genes encoding interleukin-1alpha (IL-1alpha) and IL-1beta cytokines and their implication in the onset of Alzheimer disease or in linkage disequilibrium with an as yet to be identified second locus on chromosome 2. However, these results have been associated with the sporadic forms of Alzheimer disease. Here we present data on the effects of the interleukin 1-beta exonic polymorphism (+3953) using a series of cohort healthy control samples and in vitro protein secretion assays.Entities:
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Year: 2002 PMID： 12231216 DOI： 10.1006/exmp.2002.2435
Source DB: PubMed Journal: Exp Mol Pathol ISSN： 0014-4800 Impact factor: 3.362