PURPOSE: It has been reported that genistein, an isoflavone used in soybeans, has antiprostate cancer effects. Genistein Combined Polysaccharide (GCP trade mark; AMino Up, Sapporo, Japan), a nutritional supplement manufactured in Japan, is composed of genistein and a polysaccharide obtained from basidiomycetes (mycelia) that grows in a variety of mushrooms. METHODS: We report a case of a patient with a biopsy proven prostate cancer showing clinical and pathologic evidence of regression following administration of GCP. The patient was enrolled in an Institutional Review Board (IRB)-approved protocol and received GCP for 6 weeks prior to radical prostatectomy. RESULTS: The patient's prostate-specific antigen (PSA) decreased from an initial value of 19.7 to 4.2 ng/mL after 44 days of low-dose GCP. No cancer was identified in the radical prostatectomy specimen and no side effects were observed in this patient. CONCLUSION: This case suggests that GCP, which has shown potent inhibitory effects against prostate cancer in vitro, may have some potential activity in the treatment and prevention of prostate cancer.
PURPOSE: It has been reported that genistein, an isoflavone used in soybeans, has antiprostate cancer effects. Genistein Combined Polysaccharide (GCP trade mark; AMino Up, Sapporo, Japan), a nutritional supplement manufactured in Japan, is composed of genistein and a polysaccharide obtained from basidiomycetes (mycelia) that grows in a variety of mushrooms. METHODS: We report a case of a patient with a biopsy proven prostate cancer showing clinical and pathologic evidence of regression following administration of GCP. The patient was enrolled in an Institutional Review Board (IRB)-approved protocol and received GCP for 6 weeks prior to radical prostatectomy. RESULTS: The patient's prostate-specific antigen (PSA) decreased from an initial value of 19.7 to 4.2 ng/mL after 44 days of low-dose GCP. No cancer was identified in the radical prostatectomy specimen and no side effects were observed in this patient. CONCLUSION: This case suggests that GCP, which has shown potent inhibitory effects against prostate cancer in vitro, may have some potential activity in the treatment and prevention of prostate cancer.
Authors: Ralph W deVere White; Alexander Tsodikov; Eschelle C Stapp; Stephanie E Soares; Hajime Fujii; Robert M Hackman Journal: Nutr Cancer Date: 2010 Impact factor: 2.900
Authors: Benjamin A Mooso; Ruth L Vinall; Clifford G Tepper; Rosalinda M Savoy; Jean P Cheung; Sheetal Singh; Salma Siddiqui; Yu Wang; Roble G Bedolla; Anthony Martinez; Maria Mudryj; Hsing-Jien Kung; Ralph W Devere White; Paramita M Ghosh Journal: Endocr Relat Cancer Date: 2012-11-09 Impact factor: 5.678
Authors: Courtney J Berg; David J Habibian; Aaron E Katz; Kaitlin E Kosinski; Anthony T Corcoran; Andrew S Fontes Journal: J Nutr Metab Date: 2016-05-05
Authors: Neelu Batra; Anhao Sam; Tibebe Woldemariam; George Talbott; Ralph W de Vere White; Paramita M Ghosh; Nilesh W Gaikwad; Simeon O Kotchoni; Ruth L Vinall Journal: Biomedicines Date: 2020-08-11