Literature DB >> 12230882

Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.

Akira Mitsui1, Junji Hamuro, Hajime Nakamura, Norihiko Kondo, Yoko Hirabayashi, Sonoko Ishizaki-Koizumi, Tadashi Hirakawa, Tohru Inoue, Junji Yodoi.   

Abstract

Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of the protein in a variety of stresses. Bone marrow cells from TRX-Tg mice were more resistant to ultraviolet C-induced cytocide compared with those from wild type (WT) C57BL/6 mice. TRX-Tg mice exhibited extended median and maximum life spans compared with WT mice. Telomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice. These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals.

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Year:  2002        PMID： 12230882     DOI： 10.1089/15230860260220201

Source DB:  PubMed          Journal:  Antioxid Redox Signal        ISSN： 1523-0864            Impact factor:   8.401


  80 in total

1.  Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution.

Authors:  Ningfei An; Michael G Janech; Alison M Bland; John Lazarchick; John M Arthur; Yubin Kang
Journal:  Exp Hematol       Date:  2013-08-27       Impact factor: 3.084

2.  PaTrx1 and PaTrx3, two cytosolic thioredoxins of the filamentous ascomycete Podospora anserina involved in sexual development and cell degeneration.

Authors:  Fabienne Malagnac; Benjamin Klapholz; Philippe Silar
Journal:  Eukaryot Cell       Date:  2007-10-12

Review 3.  p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria.

Authors:  Paolo Pinton; Rosario Rizzuto
Journal:  Cell Cycle       Date:  2007-11-20       Impact factor: 4.534

Review 4.  Aging and the immune system.

Authors:  Reginald M Gorczynski; Ender Terzioglu
Journal:  Int Urol Nephrol       Date:  2008-08-06       Impact factor: 2.370

Review 5.  Detoxification reactions: relevance to aging.

Authors:  Piotr Zimniak
Journal:  Ageing Res Rev       Date:  2008-05-02       Impact factor: 10.895

Review 6.  Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System.

Authors:  Xiaoyuan Ren; Lili Zou; Xu Zhang; Vasco Branco; Jun Wang; Cristina Carvalho; Arne Holmgren; Jun Lu
Journal:  Antioxid Redox Signal       Date:  2017-05-18       Impact factor: 8.401

Review 7.  Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent.

Authors:  Karl A Rodriguez; Ewa Wywial; Viviana I Perez; Adriant J Lambert; Yael H Edrey; Kaitlyn N Lewis; Kelly Grimes; Merry L Lindsey; Martin D Brand; Rochelle Buffenstein
Journal:  Curr Pharm Des       Date:  2011       Impact factor: 3.116

Review 8.  Involvement of redox state in the aging of Drosophila melanogaster.

Authors:  William C Orr; Svetlana N Radyuk; Rajindar S Sohal
Journal:  Antioxid Redox Signal       Date:  2013-04-06       Impact factor: 8.401

Review 9.  Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories.

Authors:  Gregory J Brewer
Journal:  Exp Gerontol       Date:  2009-11-27       Impact factor: 4.032

10.  Extension of mouse lifespan by overexpression of catalase.

Authors:  Samuel E Schriner; Nancy J Linford
Journal:  Age (Dordr)       Date:  2006-06-22
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