| Literature DB >> 1222950 |
T Mori, H Kobayashi, T Nishimura, T S Mori, G Fujii, T Inou.
Abstract
Effect of sex steroids, progesterone and estradiol-17beta, on transformation of human lymphocytes induced by PHA was investigated. Responses of peripheral lymphocytes from non-pregnant women to PHA was markedly reduced in the presence of progesterone at a concentration of 10(3) or 10(4) ng/ml. Estradiol-17beta, on the other hand, had no effects on the PHA-induced transformation under the present experimental conditions. The immunosuppressive property of progesterone may contribute to depression of maternal cell-mediated immunity against fetus during pregnancy.Entities:
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Year: 1975 PMID： 1222950 DOI： 10.3109/08820137509055790
Source DB: PubMed Journal: Immunol Commun ISSN： 0090-0877