Literature DB >> 12228317

Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria.

Benjamin Stoelcker1, Thomas Hehlgans, Karin Weigl, Horst Bluethmann, Georges E Grau, Daniela N Männel.   

Abstract

Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria.

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Year:  2002        PMID： 12228317      PMCID： PMC128326          DOI： 10.1128/IAI.70.10.5857-5859.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

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