Literature DB >> 12228025

The Pathophysiology and Treatment of Candida Sepsis.

Brad Spellberg1, John E. Edwards.   

Abstract

Sepsis can occur during disseminated candidiasis, but its pathogenesis differs from that caused by typical prokaryotic pathogens. Complex interactions between defects in host defense and "relative" virulence factors expressed by Candida lead to dissemination of the saprophyte to parenchymal organs, and subsequently to onset of multiorgan failure. This review focuses first on the pathophysiology of Candida sepsis, detailing current understanding of host-pathogen interactions. We then consider the choice of antifungal and supportive treatments.

Entities:  

Year:  2002        PMID： 12228025     DOI： 10.1007/s11908-002-0005-3

Source DB:  PubMed          Journal:  Curr Infect Dis Rep        ISSN： 1523-3847            Impact factor:   3.725


  121 in total

1.  Recovery from pulmonary moniliasis following serum therapy.

Authors:  J S HIATT; D S MARTIN
Journal:  J Am Med Assoc       Date:  1946-01-26

Review 2.  International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections.

Authors:  J E Edwards; G P Bodey; R A Bowden; T Büchner; B E de Pauw; S G Filler; M A Ghannoum; M Glauser; R Herbrecht; C A Kauffman; S Kohno; P Martino; F Meunier; T Mori; M A Pfaller; J H Rex; T R Rogers; R H Rubin; J Solomkin; C Viscoli; T J Walsh; M White
Journal:  Clin Infect Dis       Date:  1997-07       Impact factor: 9.079

3.  Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group.

Authors:  T J Walsh; R W Finberg; C Arndt; J Hiemenz; C Schwartz; D Bodensteiner; P Pappas; N Seibel; R N Greenberg; S Dummer; M Schuster; J S Holcenberg
Journal:  N Engl J Med       Date:  1999-03-11       Impact factor: 91.245

4.  Burn-associated Candida albicans infection caused by CD30+ type 2 T cells.

Authors:  M Kobayashi; H Kobayashi; D N Herndon; R B Pollard; F Suzuki
Journal:  J Leukoc Biol       Date:  1998-06       Impact factor: 4.962

Review 5.  Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS)

Authors:  R C Bone
Journal:  Ann Intern Med       Date:  1996-10-15       Impact factor: 25.391

6.  The role of phagocytic cells in resistance to disseminated candidiasis in granulocytopenic mice.

Authors:  J Jensen; T Warner; E Balish
Journal:  J Infect Dis       Date:  1994-10       Impact factor: 5.226

7.  Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.

Authors:  T J Walsh; J W Hiemenz; N L Seibel; J R Perfect; G Horwith; L Lee; J L Silber; M J DiNubile; A Reboli; E Bow; J Lister; E J Anaissie
Journal:  Clin Infect Dis       Date:  1998-06       Impact factor: 9.079

8.  Differential systemic and intrapulmonary TNF-alpha production in Candida sepsis during immunosuppression.

Authors:  A J Lechner; T L Tredway; D S Brink; C A Klein; G M Matuschak
Journal:  Am J Physiol       Date:  1992-11

9.  Cytokine appearance in human endotoxemia and primate bacteremia.

Authors:  D G Hesse; K J Tracey; Y Fong; K R Manogue; M A Palladino; A Cerami; G T Shires; S F Lowry
Journal:  Surg Gynecol Obstet       Date:  1988-02

10.  Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents.

Authors:  G D Martich; R L Danner; M Ceska; A F Suffredini
Journal:  J Exp Med       Date:  1991-04-01       Impact factor: 14.307
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  11 in total

Review 1.  An insight into the antifungal pipeline: selected new molecules and beyond.

Authors:  Luis Ostrosky-Zeichner; Arturo Casadevall; John N Galgiani; Frank C Odds; John H Rex
Journal:  Nat Rev Drug Discov       Date:  2010-08-20       Impact factor: 84.694

2.  The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice.

Authors:  Brad J Spellberg; Ashraf S Ibrahim; Valentina Avenissian; Scott G Filler; Carter L Myers; Yue Fu; John E Edwards
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

3.  The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis.

Authors:  Ashraf S Ibrahim; Brad J Spellberg; Valentina Avanesian; Yue Fu; John E Edwards
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

4.  Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity.

Authors:  Ashraf S Ibrahim; Brad J Spellberg; Valentina Avenissian; Yue Fu; Scott G Filler; John E Edwards
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

5.  Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis.

Authors:  Brad Spellberg; Douglas Johnston; Quynh Trang Phan; John E Edwards; Samuel W French; Ashraf S Ibrahim; Scott G Filler
Journal:  Infect Immun       Date:  2003-10       Impact factor: 3.441

6.  Fungal Endocarditis.

Authors:  Eyal Nadir; Ethan Rubinstein
Journal:  Curr Infect Dis Rep       Date:  2004-08       Impact factor: 3.725

7.  Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages.

Authors:  Lili Feng; Yi Sun; Pingping Song; Lisha Xu; Xingxin Wu; Xuefeng Wu; Yan Shen; Yang Sun; Lingdong Kong; Xudong Wu; Qiang Xu
Journal:  Br J Pharmacol       Date:  2018-12-04       Impact factor: 8.739

8.  Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis.

Authors:  Gema Martin-Manso; Dhammika H M L P Navarathna; Susana Galli; David R Soto-Pantoja; Svetlana A Kuznetsova; Maria Tsokos; David D Roberts
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

9.  Hosting infection: experimental models to assay Candida virulence.

Authors:  Donna M Maccallum
Journal:  Int J Microbiol       Date:  2011-12-22

10.  A novel glyco-conjugate vaccine against fungal pathogens.

Authors:  Antonella Torosantucci; Carla Bromuro; Paola Chiani; Flavia De Bernardis; Francesco Berti; Chiara Galli; Francesco Norelli; Cinzia Bellucci; Luciano Polonelli; Paolo Costantino; Rino Rappuoli; Antonio Cassone
Journal:  J Exp Med       Date:  2005-09-05       Impact factor: 14.307
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