Literature DB >> 12227863

Macro-alkaline phosphatase due to IgG kappa complex: demonstration with polyethylene glycol precipitation and immunofixation.

M C Owen1, L S Pike, P M George, M L Barclay, C M Florkowski.   

Abstract

An otherwise unexplained, persistently elevated plasma alkaline phosphatase concentration in a 71-year-old woman was found to be attributable to the presence of macro-alkaline phosphatase using polyethylene glycol precipitation. Gel filtration showed two high MW peaks with masses of about 330 kDa and 560 kDa. The alkaline phosphatase (ALP) complex was characterized by immunoelectrophoresis as a complex with IgG with kappa light chains.

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Year:  2002        PMID： 12227863     DOI： 10.1258/000456302320314584

Source DB:  PubMed          Journal:  Ann Clin Biochem        ISSN： 0004-5632            Impact factor:   2.057


  2 in total

1.  Detection and characterization of estradiol (E2) and unconjugated estriol (uE3) immunoassay interference due to anti-bovine alkaline phosphatase (ALP) antibodies.

Authors:  Anu S Maharjan; Sara P Wyness; Julie A Ray; Tanya L Willcox; Jonathan D Seiter; Jonathan R Genzen
Journal:  Pract Lab Med       Date:  2019-08-29

2.  Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance.

Authors:  I Ramasamy
Journal:  Case Rep Hematol       Date:  2020-01-31
  2 in total

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