Literature DB >> 12227212

Tularemia. A pathogen in nature and a biological weapon.

Gaylene Bouska Altman1.   

Abstract

Tularemia as a potential biological weapon is of great concern because F. tularensis is a hardy organism that can be spread with a small inoculum. In addition, tularemia can be contracted through nature, predominately in rural areas. This disease can be spread by a wide variety of animals and can range from skin lesions to multi-organ involvement. The severity varies with amount of inocula, the virulence of the bacterium, and the port of entry. Exposure to aerosolized forms of F. tularensis, the major concern with bioterroism, can rapidly lead to respiratory failure and death. Untreated, other forms of tularemia can spread through the blood stream to other organs, leading to sepsis and death. Early recognition and treatment is tantamount to treatment and prevention of morbidity and mortality. Occupational health nurses are on the front line and must be assertive in identifying risk factors associated with exposure. Furthermore, education of the general population about exposure through nature can potentially decrease the incidence of tularemia. Occupational health nurses, as one of the largest health specialties in the workplace, may be the first contact for the exposed individual. Tularemia is treatable with knowledge of prevention, astute assessment, prompt identification, and treatment. Combined, they are powerful nursing tools in achieving optimal outcomes.

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Mesh:

Year:  2002        PMID: 12227212

Source DB:  PubMed          Journal:  AAOHN J        ISSN: 0891-0162


  4 in total

1.  Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS.

Authors:  Michael D Valentino; Lucinda L Hensley; Denise Skrombolas; Pamela L McPherson; Matthew D Woolard; Thomas H Kawula; Jeffrey A Frelinger; John G Frelinger
Journal:  Mol Immunol       Date:  2009-02-23       Impact factor: 4.407

2.  Development of a Multivalent Subunit Vaccine against Tularemia Using Tobacco Mosaic Virus (TMV) Based Delivery System.

Authors:  Sukalyani Banik; Ahd Ahmed Mansour; Ragavan Varadharajan Suresh; Sherri Wykoff-Clary; Meenakshi Malik; Alison A McCormick; Chandra Shekhar Bakshi
Journal:  PLoS One       Date:  2015-06-22       Impact factor: 3.240

3.  Intranasal administration of a two-dose adjuvanted multi-antigen TMV-subunit conjugate vaccine fully protects mice against Francisella tularensis LVS challenge.

Authors:  Alison A McCormick; Aisha Shakeel; Chris Yi; Hardeep Kaur; Ahd M Mansour; Chandra Shekhar Bakshi
Journal:  PLoS One       Date:  2018-04-23       Impact factor: 3.240

4.  Nlrp3 Increases the Host's Susceptibility to Tularemia.

Authors:  Ragavan V Suresh; Elizabeth W Bradley; Matthew Higgs; Vincenzo C Russo; Maha Alqahtani; Wiehua Huang; Chandra Shekhar Bakshi; Meenakshi Malik
Journal:  Front Microbiol       Date:  2021-10-06       Impact factor: 6.064

  4 in total

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