Literature DB >> 12225942

Ventilator-induced lung injury: in vivo and in vitro mechanisms.

Michael A Matthay1, Sunita Bhattacharya, Donald Gaver, Lorraine B Ware, Lina H K Lim, Olga Syrkina, Fabien Eyal, Rolf Hubmayr.   

Abstract

A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.

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Mesh：

Year:  2002        PMID： 12225942     DOI： 10.1152/ajplung.00154.2002

Source DB:  PubMed          Journal:  Am J Physiol Lung Cell Mol Physiol        ISSN： 1040-0605            Impact factor:   5.464


  47 in total

1.  In situ enhancement of pulmonary surfactant function using temporary flow reversal.

Authors:  Henry W Glindmeyer; Bradford J Smith; Donald P Gaver
Journal:  J Appl Physiol (1985)       Date:  2011-10-13

2.  Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability.

Authors:  Anna A Birukova; Panfeng Fu; Junjie Xing; Bakhtiyor Yakubov; Ivan Cokic; Konstantin G Birukov
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2010-03-26       Impact factor: 5.464

3.  Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch.

Authors:  Anna A Birukova; Santipongse Chatchavalvanich; Alexander Rios; Kamon Kawkitinarong; Joe G N Garcia; Konstantin G Birukov
Journal:  Am J Pathol       Date:  2006-05       Impact factor: 4.307

Review 4.  Low-tidal-volume ventilation in the acute respiratory distress syndrome.

Authors:  Atul Malhotra
Journal:  N Engl J Med       Date:  2007-09-13       Impact factor: 91.245

5.  Computational Models of Ventilator Induced Lung Injury and Surfactant Dysfunction.

Authors:  Jason H T Bates; Bradford J Smith; Gilman B Allen
Journal:  Drug Discov Today Dis Models       Date:  2014-04-29

6.  Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling.

Authors:  Anna A Birukova; Panfeng Fu; Junjie Xing; Ivan Cokic; Konstantin G Birukov
Journal:  Transl Res       Date:  2010-01       Impact factor: 7.012

Review 7.  Pulmonary endothelium in acute lung injury: from basic science to the critically ill.

Authors:  S E Orfanos; I Mavrommati; I Korovesi; C Roussos
Journal:  Intensive Care Med       Date:  2004-07-16       Impact factor: 17.440

8.  Modeling the Progression of Epithelial Leak Caused by Overdistension.

Authors:  Katharine L Hamlington; Baoshun Ma; Bradford J Smith; Jason H T Bates
Journal:  Cell Mol Bioeng       Date:  2016-01-19       Impact factor: 2.321

9.  Elastin Cables Define the Axial Connective Tissue System in the Murine Lung.

Authors:  Willi Wagner; Robert D Bennett; Maximilian Ackermann; Alexandra B Ysasi; Janeil Belle; Cristian D Valenzuela; Andreas Pabst; Akira Tsuda; Moritz A Konerding; Steven J Mentzer
Journal:  Anat Rec (Hoboken)       Date:  2015-09-08       Impact factor: 2.064

Review 10.  Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins.

Authors:  Srikanth Pendyala; Peter V Usatyuk; Irina A Gorshkova; Joe G N Garcia; Viswanathan Natarajan
Journal:  Antioxid Redox Signal       Date:  2009-04       Impact factor: 8.401
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