| Literature DB >> 12225900 |
C W Ang1, A P Tio-Gillen, J Groen, P Herbrink, B C Jacobs, R Van Koningsveld, A D M E Osterhaus, F G A Van der Meché, P A van Doorn.
Abstract
Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with MP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP.Entities:
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Year: 2002 PMID： 12225900 DOI： 10.1016/s0165-5728(02)00209-6
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478