Literature DB >> 12222878

Bone marrow-derived endothelial progenitor cells for vascular regeneration.

Toshinori Murayama1, Takayuki Asahara.   

Abstract

It has recently been demonstrated that postnatal neovascularization is not restricted to angiogenesis, but also includes vasculogenesis. During adult vasculogenesis, bone marrow (BM)-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation in response to certain cytokines and/or tissue ischemia, and incorporate into sites of neovascularization. EPCs have also been investigated as therapeutic agents in a 'supply-side' approach to promoting neovascularization under pathological conditions. This review highlights the discovery of BM-derived EPCs and their therapeutic potential for vascular regeneration.

Entities:  

Mesh：

Year:  2002        PMID： 12222878

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


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