Literature DB >> 12222867

Extrachromosomal plasmid vectors for gene therapy.

Stephanie M Stoll1, Michele P Calos.   

Abstract

Extrachromosomal DNA is becoming widely utilized as a gene therapy vector. Plasmid DNA offers multiple advantages over viral gene therapy vectors, including large packaging capacity, stability without integration and reduced toxicity. Furthermore, plasmid DNA can be delivered to many different tissues, using a variety of delivery techniques currently being developed. This review will discuss the advantages of extrachromosomal DNA as a gene therapy vector, highlighting recent advances and successes in its use in vivo.

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Year:  2002        PMID： 12222867

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  6 in total

1.  Foe turned friend: multiple functional roles attributable to hyper-activating stem cell factor receptor mutant in regeneration of the haematopoietic cell compartment.

Authors:  S Pati; O P Kalra; A Mukhopadhyay
Journal:  Cell Prolif       Date:  2011-02       Impact factor: 6.831

2.  An S/MAR-based L1 retrotransposition cassette mediates sustained levels of insertional mutagenesis without suffering from epigenetic silencing of DNA methylation.

Authors:  Danny Rangasamy
Journal:  Epigenetics       Date:  2010-10-01       Impact factor: 4.528

3.  Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline.

Authors:  Kevin R Smith
Journal:  Int J Med Sci       Date:  2004-06-01       Impact factor: 3.738

4.  Rearranging the centromere of the human Y chromosome with phiC31 integrase.

Authors:  Sunir Malla; Felix Dafhnis-Calas; John F Y Brookfield; Margaret C M Smith; William R A Brown
Journal:  Nucleic Acids Res       Date:  2005-10-24       Impact factor: 16.971

5.  A Flow Cytometric Method to Determine Transfection Efficiency.

Authors:  Wenli Mu; Stefanie Homann; Christian Hofmann; Alexandr Gorin; Diana Huynh; Otto Orlean Yang; Theodoros Kelesidis
Journal:  Bio Protoc       Date:  2019-05-20

6.  A novel rapid and reproducible flow cytometric method for optimization of transfection efficiency in cells.

Authors:  Stefanie Homann; Christian Hofmann; Aleksandr M Gorin; Huy Cong Xuan Nguyen; Diana Huynh; Phillip Hamid; Neil Maithel; Vahe Yacoubian; Wenli Mu; Athanasios Kossyvakis; Shubhendu Sen Roy; Otto Orlean Yang; Theodoros Kelesidis
Journal:  PLoS One       Date:  2017-09-01       Impact factor: 3.752
  6 in total

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