| Literature DB >> 12222685 |
Abstract
A brief review of the molecular mechanisms of nickel carcinogenesis is presented. Molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of nickel-induced gene silencing by DNA hypermethylation in mammalian cells and by its ability to inhibit histone acetylation. Model systems designed to study the molecular mechanism of gene silencing are discussed.Entities:
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Year: 2002 PMID： 12222685 DOI： 10.1515/BC.2002.102
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915