Literature DB >> 1222217

The oncostatic and immunosuppressive action of new nitrosourea derivatives containing sugar radicals.

J L Imbach, J L Montero, A Moruzzi, B Serrou, E Chenu, M Hayat, G Mathe.   

Abstract

Four new nitrosourea derivatives represent an appreciable progress in the treatment and cure of L1210 leukemia. Their therapeutic index is higher than that of CCNU and MeCCNU. Of these compounds, RFCNU may prove the most promising, as its therapeutic index is the highest of those for all the four compounds studied; moreover, unlike the other products, it is not immunosuppressive, whether administered before or after the antigen.

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Year:  1975        PMID: 1222217

Source DB:  PubMed          Journal:  Biomedicine        ISSN: 0300-0893


  6 in total

1.  Comparative pharmacology of three new nitrosourea analogues: RFCNU, RPCNU, and chlorozotocin. I. Oncostatic effects in mice.

Authors:  M Hayat; C Bourut; E Chenu; J L Montero; J L Imbach; J S MacDonald; G Mathé
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

Review 2.  New cancer chemotherapy drugs in Europe.

Authors:  G Mathé; L M van Putten
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

3.  The multiplication of analogs, the best strategy for rapid extension of the oncostatic arsenal. How can they be compared experimentally?

Authors:  G Mathé; C Jasmin
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

4.  Chemotherapy, a double agent in respect of immune functions.

Authors:  G Mathé
Journal:  Cancer Chemother Pharmacol       Date:  1978       Impact factor: 3.333

5.  Phase I trials in clinical oncostatic pharmacology.

Authors:  P Ribaud; G Mathé
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333

6.  Difference in effect of single immunosuppressive agents (cyclophosphamide, CCNU, 5-FU) on peripheral blood immune cell parameters and central nervous system immunoglobulin synthesis rate in patients with multiple sclerosis.

Authors:  W W Shih; R W Baumhefner; W W Tourtellotte; C M Haskell; E L Korn; J L Fahey
Journal:  Clin Exp Immunol       Date:  1983-07       Impact factor: 4.330

  6 in total

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