Literature DB >> 12221603

Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones.

Thomas J Schmidt1, Reto Brun, Günter Willuhn, Sami A Khalid.   

Abstract

The anti-trypanosomal activity of six sesquiterpene lactones (helenalin, mexicanin I, 11alpha,13-dihydrohelenalin acetate, chamissonolide, ivalin and isoalantolactone) against the African Trypanosoma brucei rhodesiense and American T. cruzi was investigated. All tested compounds were found active towards both parasites, the former being generally more sensitive. Helenalin was the most active compound in the series with IC50 values of 0.051 and 0.695 microM against T. brucei rhodesiense and T. cruzi, respectively. The low IC50 value for T. b. rhodesiense indicates that helenalin type compounds may be interesting candidates for further evaluation.

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Year:  2002        PMID： 12221603     DOI： 10.1055/s-2002-33799

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  21 in total

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2.  Untargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase.

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Journal:  Metabolomics       Date:  2019-04-04       Impact factor: 4.290

3.  Function-Oriented and Modular (+/-)-cis-Pseudoguaianolide Synthesis: Discovery of New Nrf2 Activators and NF-κB Inhibitors.

Authors:  Fabien Emmetiere; Ranjala Ratnayake; Henry A M Schares; Katherine F M Jones; Emily Bevan-Smith; Hendrik Luesch; Daniel A Harki; Alexander J Grenning
Journal:  Chemistry       Date:  2021-02-26       Impact factor: 5.236

Review 4.  Stevia Genus: Phytochemistry and Biological Activities Update.

Authors:  Jimena Borgo; Laura C Laurella; Florencia Martini; Cesar A N Catalán; Valeria P Sülsen
Journal:  Molecules       Date:  2021-05-06       Impact factor: 4.411

5.  In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense.

Authors:  Thomas J Schmidt; Fernando B Da Costa; Norberto P Lopes; Marcel Kaiser; Reto Brun
Journal:  Antimicrob Agents Chemother       Date:  2013-10-28       Impact factor: 5.191

6.  Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones.

Authors:  Imke F Wulsten; Thais A Costa-Silva; Juliana T Mesquita; Marta L Lima; Mariana K Galuppo; Noemi N Taniwaki; Samanta E T Borborema; Fernando B Da Costa; Thomas J Schmidt; Andre G Tempone
Journal:  Molecules       Date:  2017-04-25       Impact factor: 4.411

7.  δ-Lactones-A New Class of Compounds That Are Toxic to E. coli K12 and R2-R4 Strains.

Authors:  Paweł Kowalczyk; Barbara Gawdzik; Damian Trzepizur; Mateusz Szymczak; Grzegorz Skiba; Stanisława Raj; Karol Kramkowski; Rafał Lizut; Ryszard Ostaszewski
Journal:  Materials (Basel)       Date:  2021-05-30       Impact factor: 3.623

8.  Natural terpenoids from Ambrosia species are active in vitro and in vivo against human pathogenic trypanosomatids.

Authors:  Valeria P Sülsen; Silvia I Cazorla; Fernanda M Frank; Laura C Laurella; Liliana V Muschietti; Cesar A Catalán; Virginia S Martino; Emilio L Malchiodi
Journal:  PLoS Negl Trop Dis       Date:  2013-10-10

Review 9.  Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone.

Authors:  Azhar Rasul; Muhammad Khan; Muhammad Ali; Jiang Li; Xiaomeng Li
Journal:  ScientificWorldJournal       Date:  2013-10-27

10.  Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.

Authors:  Lionel Sacconnay; Melissa Angleviel; Giuseppe Marco Randazzo; Marcos Marçal Ferreira Queiroz; Emerson Ferreira Queiroz; Jean-Luc Wolfender; Pierre-Alain Carrupt; Alessandra Nurisso
Journal:  PLoS Negl Trop Dis       Date:  2014-02-13
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