Literature DB >> 12221089

Dynamics-modulated biological activity of transforming growth factor beta3.

Eduard V Bocharov1, Dmitry M Korzhnev, Marcel J J Blommers, Tudor Arvinte, Vladislav Yu Orekhov, Martin Billeter, Alexander S Arseniev.   

Abstract

Transforming growth factor beta3 (TGF-beta3) is an important mediator of growth, maintenance, and repair processes in human cells. Internal dynamic properties have been derived from (15)N NMR relaxation data and mapped onto the spatial structure of TGF-beta3. The pattern of internal dynamics in the structure identifies potential "hot spots" of binding free energy and reveals the importance of conformational entropy in the interaction of TGF-beta3 with the receptors. The observed internal dynamics set TGF-beta3 apart from other TGF-beta isoforms, with which it shares the same fold. These findings may explain functional differences among the various TGF-beta isoforms and thus prove essential in the search for related therapeutic agents.

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Year:  2002        PMID： 12221089     DOI： 10.1074/jbc.M206274200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  13 in total

1.  Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.

Authors:  Thomas B Thompson; Teresa K Woodruff; Theodore S Jardetzky
Journal:  EMBO J       Date:  2003-04-01       Impact factor: 11.598

2.  Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1.

Authors:  Eduard V Bocharov; Maxim L Mayzel; Pavel E Volynsky; Marina V Goncharuk; Yaroslav S Ermolyuk; Alexey A Schulga; Elena O Artemenko; Roman G Efremov; Alexander S Arseniev
Journal:  J Biol Chem       Date:  2008-08-26       Impact factor: 5.157

Review 3.  Structural Biology and Evolution of the TGF-β Family.

Authors:  Andrew P Hinck; Thomas D Mueller; Timothy A Springer
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-12-01       Impact factor: 10.005

Review 4.  Antagonism of activin by activin chimeras.

Authors:  Uwe Muenster; Radhika Korupolu; Ratindra Rastogi; Jessica Read; Wolfgang H Fischer
Journal:  Vitam Horm       Date:  2011       Impact factor: 3.421

5.  New strategy for high-level expression and purification of biologically active monomeric TGF-β1/C77S in Escherichia coli.

Authors:  Yana V Kim; Marine E Gasparian; Eduard V Bocharov; Rita V Chertkova; Elena N Tkach; Dmitry A Dolgikh; Mikhail P Kirpichnikov
Journal:  Mol Biotechnol       Date:  2015-02       Impact factor: 2.695

Review 6.  TGF-beta3 and cancer: a review.

Authors:  H G Laverty; L M Wakefield; N L Occleston; S O'Kane; M W J Ferguson
Journal:  Cytokine Growth Factor Rev       Date:  2009-08-04       Impact factor: 7.638

7.  Production, Isolation, and Structural Analysis of Ligands and Receptors of the TGF-β Superfamily.

Authors:  Tao Huang; Andrew P Hinck
Journal:  Methods Mol Biol       Date:  2016

8.  Hydrophobic core mutations in CI2 globally perturb fast side-chain dynamics similarly without regard to position.

Authors:  Matthew J Whitley; Jun Zhang; Andrew L Lee
Journal:  Biochemistry       Date:  2008-07-26       Impact factor: 3.162

9.  Dimeric structure of the transmembrane domain of glycophorin a in lipidic and detergent environments.

Authors:  K S Mineev; E V Bocharov; P E Volynsky; M V Goncharuk; E N Tkach; Ya S Ermolyuk; A A Schulga; V V Chupin; I V Maslennikov; R G Efremov; A S Arseniev
Journal:  Acta Naturae       Date:  2011-04       Impact factor: 1.845

10.  Structural and dynamic study of the transmembrane domain of the amyloid precursor protein.

Authors:  K D Nadezhdin; O V Bocharova; E V Bocharov; A S Arseniev
Journal:  Acta Naturae       Date:  2011-01       Impact factor: 1.845
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