Literature DB >> 12220878

Phenomics: fiction or the future?

Robert Gerlai1.   

Abstract

The ease with which genetic mutations can be induced in or introduced into mammalian organisms, such as the mouse, has created a significant need for phenotypic analysis. Developments in computer technology, instrumentation and bioinformatics, as well as in numerous neuroscience disciplines, will help to meet the demands set by the molecular revolution. As a result, the field of 'phenomics' is being born. This will integrate multidisciplinary research, with the goal of understanding the complex phenotypic consequences of genetic mutations at the level of the organism. This paper focuses on one of the disciplines that show promising developments, behavioral science.

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Year:  2002        PMID: 12220878     DOI: 10.1016/s0166-2236(02)02250-6

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN: 0166-2236            Impact factor:   13.837


  42 in total

1.  High-resolution yeast phenomics resolves different physiological features in the saline response.

Authors:  Jonas Warringer; Elke Ericson; Luciano Fernandez; Olle Nerman; Anders Blomberg
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-15       Impact factor: 11.205

2.  Terminological mapping for high throughput comparative biology of phenotypes.

Authors:  Y A Lussier; J Li
Journal:  Pac Symp Biocomput       Date:  2004

3.  Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration.

Authors:  A Bindewald; S Schmitz-Valckenberg; J J Jorzik; J Dolar-Szczasny; H Sieber; C Keilhauer; A W A Weinberger; S Dithmar; D Pauleikhoff; U Mansmann; S Wolf; F G Holz
Journal:  Br J Ophthalmol       Date:  2005-07       Impact factor: 4.638

4.  Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.

Authors:  Silvia Mandillo; Valter Tucci; Sabine M Hölter; Hamid Meziane; Mumna Al Banchaabouchi; Magdalena Kallnik; Heena V Lad; Patrick M Nolan; Abdel-Mouttalib Ouagazzal; Emma L Coghill; Karin Gale; Elisabetta Golini; Sylvie Jacquot; Wojtek Krezel; Andy Parker; Fabrice Riet; Ilka Schneider; Daniela Marazziti; Johan Auwerx; Steve D M Brown; Pierre Chambon; Nadia Rosenthal; Glauco Tocchini-Valentini; Wolfgang Wurst
Journal:  Physiol Genomics       Date:  2008-05-27       Impact factor: 3.107

5.  An automated predator avoidance task in zebrafish.

Authors:  Omar Ahmed; Diane Seguin; Robert Gerlai
Journal:  Behav Brain Res       Date:  2010-07-30       Impact factor: 3.332

Review 6.  Whole-Organism Cellular Pathology: A Systems Approach to Phenomics.

Authors:  K C Cheng; S R Katz; A Y Lin; X Xin; Y Ding
Journal:  Adv Genet       Date:  2016-07-29       Impact factor: 1.944

Review 7.  Common Polymorphisms in the Age of Research Domain Criteria (RDoC): Integration and Translation.

Authors:  Charles E Glatt; Francis S Lee
Journal:  Biol Psychiatry       Date:  2015-01-08       Impact factor: 13.382

8.  In search of optimal fear inducing stimuli: Differential behavioral responses to computer animated images in zebrafish.

Authors:  Ruxandra M Luca; Robert Gerlai
Journal:  Behav Brain Res       Date:  2011-09-08       Impact factor: 3.332

Review 9.  Zebrafish antipredatory responses: a future for translational research?

Authors:  Robert Gerlai
Journal:  Behav Brain Res       Date:  2009-10-15       Impact factor: 3.332

10.  The social zebrafish: behavioral responses to conspecific, heterospecific, and computer animated fish.

Authors:  Cristina Saverino; Robert Gerlai
Journal:  Behav Brain Res       Date:  2008-03-18       Impact factor: 3.332

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