Literature DB >> 12220870

Perisynaptic asymmetry of glia: new insights into glutamate signalling.

Dmitri A Rusakov1, Knut Petter Lehre.   

Abstract

Synaptically released glutamate activates extrasynaptic receptors; such actions are controlled by glutamate uptake. Recent experimental findings show that there are many more glutamate transporters on the postsynaptic than presynaptic side of the vicinity of central synapses. This asymmetry favours activation of axonal, as opposed to dendritic, extrasynaptic glutamate receptors, thus imposing rule on information processing in the brain.

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Year:  2002        PMID： 12220870     DOI： 10.1016/s0166-2236(02)02230-0

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  9 in total

Review 1.  Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function?

Authors:  A Galvan; M Kuwajima; Y Smith
Journal:  Neuroscience       Date:  2006-10-23       Impact factor: 3.590

Review 2.  Astrocytes Control Synapse Formation, Function, and Elimination.

Authors:  Won-Suk Chung; Nicola J Allen; Cagla Eroglu
Journal:  Cold Spring Harb Perspect Biol       Date:  2015-02-06       Impact factor: 10.005

3.  Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats.

Authors:  D A Mitrano; C Arnold; Y Smith
Journal:  Neuroscience       Date:  2008-03-29       Impact factor: 3.590

4.  Glutamate transporter studies reveal the pruning of metabotropic glutamate receptors and absence of AMPA receptor desensitization at mature calyx of Held synapses.

Authors:  Robert Renden; Holger Taschenberger; Nagore Puente; Dmitri A Rusakov; Robert Duvoisin; Lu-Yang Wang; Knut P Lehre; Henrique von Gersdorff
Journal:  J Neurosci       Date:  2005-09-14       Impact factor: 6.167

Review 5.  Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling.

Authors:  Richard Bridges; Victoria Lutgen; Doug Lobner; David A Baker
Journal:  Pharmacol Rev       Date:  2012-07       Impact factor: 25.468

6.  Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia.

Authors:  Jonathan Kipnis; Hila Avidan; Rachel R Caspi; Michal Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-26       Impact factor: 11.205

7.  The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.

Authors:  Michele Bellesi; Fiorenzo Conti
Journal:  Neuropsychopharmacology       Date:  2010-01-13       Impact factor: 7.853

8.  Synaptic microcircuitry of tyrosine hydroxylase-containing neurons and terminals in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.

Authors:  Maney Mazloom; Yoland Smith
Journal:  J Comp Neurol       Date:  2006-04-01       Impact factor: 3.215

9.  Heterogeneity and specificity of presynaptic Ca2+ current modulation by mGluRs at individual hippocampal synapses.

Authors:  Dmitri A Rusakov; Axel Wuerz; Dimitri M Kullmann
Journal:  Cereb Cortex       Date:  2004-03-28       Impact factor: 5.357
  9 in total

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