OBJECTIVE: This study aimed at relating the pattern of response to dietary plant sterol ester (PSE) treatment of plasma lipids concentrations and apo E polymorphisms. METHODS:Patients (20-60y old: 50 women; 10 men) with primary moderate hypercholesterolemia werefed margarine (20g/d), received no treatment (placebo), and were fed PSE (2.8g/d = 1.68 phytosterols), during 3 periods of 4 weeks each, in a crossover, double-blind study. DNA was extracted from white blood cells for the apo E polymorphisms. RESULTS:PSE treatment significantly lowered TC and LDL-C 10% and 12%, respectively, in relation to the baseline, and 6% and 8% in relation to the placebo phase, but HDL-C and TG levels were not modified. In regard to the apo E genotyping, no significant difference occurred between apo E 3/3 and apo E (3/4). CONCLUSION:Dietary plant sterol ester (PSE) treatment reduced cholesterolemia, and the reduction of LDL-C in absolute values was more pronounced when the initial LDL - C concentration were elevated.
RCT Entities:
OBJECTIVE: This study aimed at relating the pattern of response to dietary plant sterol ester (PSE) treatment of plasma lipids concentrations and apo E polymorphisms. METHODS:Patients (20-60y old: 50 women; 10 men) with primary moderate hypercholesterolemia were fed margarine (20g/d), received no treatment (placebo), and were fed PSE (2.8g/d = 1.68 phytosterols), during 3 periods of 4 weeks each, in a crossover, double-blind study. DNA was extracted from white blood cells for the apo E polymorphisms. RESULTS: PSE treatment significantly lowered TC and LDL-C 10% and 12%, respectively, in relation to the baseline, and 6% and 8% in relation to the placebo phase, but HDL-C and TG levels were not modified. In regard to the apo E genotyping, no significant difference occurred between apo E 3/3 and apo E (3/4). CONCLUSION: Dietary plant sterol ester (PSE) treatment reduced cholesterolemia, and the reduction of LDL-C in absolute values was more pronounced when the initial LDL - C concentration were elevated.
Authors: Angela Oliveira Godoy Ilha; Valeria Sutti Nunes; Milessa Silva Afonso; Edna Regina Nakandakare; Guilherme da Silva Ferreira; Renata de Paula Assis Bombo; Ricardo Rodrigues Giorgi; Roberta Marcondes Machado; Eder Carlos Rocha Quintão; Ana Maria Lottenberg Journal: Nutrients Date: 2020-05-22 Impact factor: 5.717
Authors: Valéria Sutti Nunes; Isabela M Bensenor; Paulo A Lotufo; Marisa Passarelli; Edna Regina Nakandakare; Eder Carlos Rocha Quintão Journal: Biosci Rep Date: 2020-07-31 Impact factor: 3.840
Authors: Valéria Sutti Nunes; Angela de Oliveira Godoy Ilha; Guilherme da Silva Ferreira; Renata de Paula Assis Bombo; Milessa Silva Afonso; Maria Silvia Ferrari Lavrador; Roberta Marcondes Machado; Edna Regina Nakandakare; Eder Carlos Rocha Quintão; Ana Maria Lottenberg Journal: Clinics (Sao Paulo) Date: 2022-04-06 Impact factor: 2.365