Ali F Aburahma1, Stefan P Thiele, John T Wulu. 1. Department of Vascular Surgery, Robert C. Byrd Health Sciences Center, West Virginia University, Charleston, USA.
Abstract
BACKGROUND/ PURPOSE: In spite of the conclusions of the Asymptomatic Carotid Atherosclerosis Study, some clinicians are still reluctant to recommend carotid endarterectomy (CEA) for patients with asymptomatic > or = 60% carotid stenosis (ACS). This study analyzes the natural history of 60% to 69% ACS according to ultrasonic plaque morphology and its implication on treatment. PATIENT POPULATION AND METHODS: During a 2-year period, patients with 60% to 69% ACS entered into a protocol of carotid duplex scan surveillance/clinical examination every 6 months. The ultrasonic plaque morphology was classified as heterogeneous (group A, n = 162) or homogeneous (group B, n = 229) with HDI 3000/HDI 5000 systems (Advanced Technology Laboratories, Bothwell, Wash). CEA was done if lesion progressed to > or = 70% stenosis or became symptomatic. RESULTS: Three hundred eighty-two patients (391 arteries) were followed for a mean interval of 37 months. The clinical/demographic characteristics were similar for both groups. The incidence rate of future ipsilateral strokes was significantly higher in group A than in group B: 13.6% versus 3.1% (P =.0001; odds ratio [OR], 5). Similarly, the incidence rate of all neurologic events (stroke or transient ischemic attack [TIA]) was higher in group A than in group B: 27.8% versus 6.6% (P =.0001; OR, 5.5). Progression to > or = 70% stenosis was also higher in group A than in group B: 25.3% versus 6.1% (P =.0001; OR, 5.2). Forty-four late CEAs (27.2%) were done in group A (16 for stroke, 21 for TIA, and seven for > or = 70% ACS) versus 13 (5.7%) in group B (five for stroke, seven for TIA, and one for > or = 70% ACS; P =.0001; OR, 6.2). CONCLUSION: Patients with 60% to 69% ACS with heterogeneous plaque had a higher incidence rate of late stroke, TIA, and progression to > or = 70% stenosis than patients with homogeneous plaque. Prophylactic CEA for 60% to 69% ACS may be justified if associated with heterogeneous plaque.
BACKGROUND/ PURPOSE: In spite of the conclusions of the Asymptomatic Carotid Atherosclerosis Study, some clinicians are still reluctant to recommend carotid endarterectomy (CEA) for patients with asymptomatic > or = 60% carotid stenosis (ACS). This study analyzes the natural history of 60% to 69% ACS according to ultrasonic plaque morphology and its implication on treatment. PATIENT POPULATION AND METHODS: During a 2-year period, patients with 60% to 69% ACS entered into a protocol of carotid duplex scan surveillance/clinical examination every 6 months. The ultrasonic plaque morphology was classified as heterogeneous (group A, n = 162) or homogeneous (group B, n = 229) with HDI 3000/HDI 5000 systems (Advanced Technology Laboratories, Bothwell, Wash). CEA was done if lesion progressed to > or = 70% stenosis or became symptomatic. RESULTS: Three hundred eighty-two patients (391 arteries) were followed for a mean interval of 37 months. The clinical/demographic characteristics were similar for both groups. The incidence rate of future ipsilateral strokes was significantly higher in group A than in group B: 13.6% versus 3.1% (P =.0001; odds ratio [OR], 5). Similarly, the incidence rate of all neurologic events (stroke or transient ischemic attack [TIA]) was higher in group A than in group B: 27.8% versus 6.6% (P =.0001; OR, 5.5). Progression to > or = 70% stenosis was also higher in group A than in group B: 25.3% versus 6.1% (P =.0001; OR, 5.2). Forty-four late CEAs (27.2%) were done in group A (16 for stroke, 21 for TIA, and seven for > or = 70% ACS) versus 13 (5.7%) in group B (five for stroke, seven for TIA, and one for > or = 70% ACS; P =.0001; OR, 6.2). CONCLUSION:Patients with 60% to 69% ACS with heterogeneous plaque had a higher incidence rate of late stroke, TIA, and progression to > or = 70% stenosis than patients with homogeneous plaque. Prophylactic CEA for 60% to 69% ACS may be justified if associated with heterogeneous plaque.
Authors: John D Barr; John J Connors; David Sacks; Joan C Wojak; Gary J Becker; John F Cardella; Bohdan Chopko; Jacques E Dion; Allan J Fox; Randall T Higashida; Robert W Hurst; Curtis A Lewis; Terence A S Matalon; Gary M Nesbit; J Arliss Pollock; Eric J Russell; David J Seidenwurm; Robert C Wallace Journal: AJNR Am J Neuroradiol Date: 2003 Nov-Dec Impact factor: 3.825
Authors: U Rajendra Acharya; Muthu Rama Krishnan Mookiah; S Vinitha Sree; David Afonso; Joao Sanches; Shoaib Shafique; Andrew Nicolaides; L M Pedro; J Fernandes E Fernandes; Jasjit S Suri Journal: Med Biol Eng Comput Date: 2013-01-06 Impact factor: 2.602
Authors: Jason D Allen; Katherine L Ham; Douglas M Dumont; Bantayehu Sileshi; Gregg E Trahey; Jeremy J Dahl Journal: Vasc Med Date: 2011-03-29 Impact factor: 3.239
Authors: Aditya M Sharma; Ajay Gupta; P Krishna Kumar; Jeny Rajan; Luca Saba; Ikeda Nobutaka; John R Laird; Andrew Nicolades; Jasjit S Suri Journal: Curr Atheroscler Rep Date: 2015-09 Impact factor: 5.113
Authors: Jeremy J Dahl; Douglas M Dumont; Jason D Allen; Elizabeth M Miller; Gregg E Trahey Journal: Ultrasound Med Biol Date: 2009-02-25 Impact factor: 2.998
Authors: Liz Andréa V Baroncini; Antonio Pazin Filho; Luiz O Murta Junior; Antonio R Martins; Simone G Ramos; Jesualdo Cherri; Carlos E Piccinato Journal: Cardiovasc Ultrasound Date: 2006-08-17 Impact factor: 2.062
Authors: Amit Shankar Singh; Virendra Atam; Nirdesh Jain; Besthanahalli Errapa Yathish; Malagouda R Patil; Liza Das Journal: N Am J Med Sci Date: 2013-06