Literature DB >> 12217523

A universal role for MyD88 in TLR/IL-1R-mediated signaling.

Sophie Janssens1, Rudi Beyaert.   

Abstract

The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases. Although originally identified as a myeloid-differentiation marker, MyD88 is now known to play an essential role in the innate immune response of insects and mammals. The generation of MyD88-deficient mice, as well as the identification of MyD88-related proteins and regulators of MyD88 signaling, has revealed new and important insights into the function of MyD88.

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Year:  2002        PMID： 12217523     DOI： 10.1016/s0968-0004(02)02145-x

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  134 in total

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9.  Brucella TIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP.

Authors:  Girish K Radhakrishnan; Qiqi Yu; Jerome S Harms; Gary A Splitter
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10.  The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.

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Journal:  Nat Immunol       Date:  2015-02-02       Impact factor: 25.606
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