| Literature DB >> 12217373 |
Michael A Letavic1, Brian S Bronk, Camilla D Bertsche, Jeffrey M Casavant, Hengmiao Cheng, Kirsten L Daniel, David M George, Shigeru F Hayashi, Barbara J Kamicker, Nicole L Kolosko, Laura J L Norcia, Vanessa D Oberton, Margaret A Rushing, Sheryl L Santoro.
Abstract
The stereoselective synthesis of two novel series of tribasic macrocyclic antibiotics with potent in vitro activity against Pasteurella multocida and Escherichia coli strains of bacteria is described. The in vitro activity can be significantly influenced by the nature of the substituents on the C-4" aminoalcohol, with the stereochemistry of the C-4" alcohol playing a less critical role. The effect of substitution and stereochemistry on the in vivo activity in a murine model of respiratory infection is also described.Entities:
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Year: 2002 PMID： 12217373 DOI： 10.1016/s0960-894x(02)00526-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823