| Literature DB >> 12217370 |
Michael H Serrano-Wu1, Denis R St Laurent, Yijun Chen, Stella Huang, Kin-Ray Lam, James A Matson, Charles E Mazzucco, Terry M Stickle, Thomas P Tully, Henry S Wong, Dolatrai M Vyas, Balu N Balasubramanian.
Abstract
The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of antifungal activity for these novel derivatives includes coverage of Candida albicans, Candida glabrata, and Cryptococcus neoformans.Entities:
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Year: 2002 PMID： 12217370 DOI： 10.1016/s0960-894x(02)00529-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823