Prospective age-based comparison of behavioral reactions occurring after ketamine sedation in the ED.

The study objective was to prospectively evaluate the frequency and severity of behavioral reactions occurring in children receiving ketamine sedation in the emergency department (ED). A behavioral observational study was conducted. Ketamine was given in a standardized protocol with midazolam, atropine, and a prehypnotic suggestion. Descriptions of behavioral reactions were recorded immediately after the procedure, and longitudinal follow-up was made in 1 day, 1 week, and 1 month. A total of 301 patients were enrolled. Mild reactions described as not unpleasant occurred in 7/205 (3.4%, 95% CI 0.9-5.9%) of the younger age group, and 2/96 (2.1%, 95% CI 0-5.0%) of the older age group. Unpleasant reactions occurred in 2/205 (1.0%, 95% CI 0-2.4%) of the younger age group, and 4/96 (4.2%, 95% CI 0-8.2%) of the older age group. We observed no clinically important difference in the proportion of older versus younger children experiencing behavioral reactions after IV ketamine sedation. Copyright 2002, Elsevier Science (USA). All rights reserved.