Literature DB >> 12215840

A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers.

Rene Goedde1, Stephen Sawcer, Stefan Boehringer, Bianca Miterski, Eckhart Sindern, Michael Haupts, Sebastian Schimrigk, Alastair Compston, Joerg T Epplen.   

Abstract

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with putative autoimmune aetiology and complex genetic background. Here, we report the results of a genome screen for linkage disequilibrium (LD) by using 6000 microsatellite markers in 198 HLA-DRB1*15-positive MS patients and 198 unrelated controls (pooled DNA); 4666 analysed markers could be included in the resulting association map, from which 87 revealed significant differences between MS cases and controls.

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Year:  2002        PMID： 12215840     DOI： 10.1007/s00439-002-0801-8

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  11 in total

1.  No association between synapsin III gene promoter polymorphisms and multiple sclerosis in German patients.

Authors:  Denis A Akkad; René Gödde; Jörg T Epplen
Journal:  J Neurol       Date:  2006-09-13       Impact factor: 4.849

2.  Association of the HLA region with multiple sclerosis as confirmed by a genome screen using >10,000 SNPs on DNA chips.

Authors:  René Gödde; Klaus Rohde; Christian Becker; Mahammad R Toliat; Patricia Entz; Anita Suk; Norbert Müller; Eckhart Sindern; Michael Haupts; Sebastian Schimrigk; Peter Nürnberg; Jörg T Epplen
Journal:  J Mol Med (Berl)       Date:  2005-03-16       Impact factor: 4.599

3.  A second-generation genomic screen for multiple sclerosis.

Authors:  S J Kenealy; M-C Babron; Y Bradford; N Schnetz-Boutaud; J L Haines; J B Rimmler; S Schmidt; M A Pericak-Vance; L F Barcellos; R R Lincoln; J R Oksenberg; S L Hauser; M Clanet; D Brassat; G Edan; J Yaouanq; G Semana; I Cournu-Rebeix; O Lyon-Caen; B Fontaine
Journal:  Am J Hum Genet       Date:  2004-10-19       Impact factor: 11.025

4.  A genome-wide scan in forty large pedigrees with multiple sclerosis.

Authors:  Cristen J Willer; David A Dyment; Stacey Cherny; Sreeram V Ramagopalan; Blanca M Herrera; Katie M E Morrison; A Dessa Sadovnick; Neil J Risch; George C Ebers
Journal:  J Hum Genet       Date:  2007-11-15       Impact factor: 3.172

5.  New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes.

Authors:  Peter Jagiello; Martin Gencik; Larissa Arning; Stefan Wieczorek; Erdmute Kunstmann; Elena Csernok; Wolfgang L Gross; Joerg T Epplen
Journal:  Hum Genet       Date:  2004-02-14       Impact factor: 4.132

6.  Whole-genome linkage disequilibrium screening for complex traits in horses.

Authors:  Teruaki Tozaki; Kei-ichi Hirota; Telhisa Hasegawa; Nobushige Ishida; Takashi Tobe
Journal:  Mol Genet Genomics       Date:  2007-02-22       Impact factor: 2.980

7.  An extended association screen in multiple sclerosis using 202 microsatellite markers targeting apoptosis-related genes does not reveal new predisposing factors.

Authors:  René Gödde; Stefanie Brune; Peter Jagiello; Eckhart Sindern; Michael Haupts; Sebastian Schimrigk; Norbert Müller; Jörg T Epplen
Journal:  J Negat Results Biomed       Date:  2005-09-05

8.  Association study with Wegener granulomatosis of the human phospholipase Cgamma2 gene.

Authors:  Peter Jagiello; Stefan Wieczorek; Philipp Yu; Elena Csernok; Wolfgang L Gross; Joerg T Epplen
Journal:  J Negat Results Biomed       Date:  2005-02-09

9.  Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

Authors:  J L McCauley; R L Zuvich; Y Bradford; S J Kenealy; N Schnetz-Boutaud; S G Gregory; S L Hauser; J R Oksenberg; D P Mortlock; M A Pericak-Vance; J L Haines
Journal:  Genes Immun       Date:  2009-07-23       Impact factor: 2.676

10.  Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population.

Authors:  Masoomeh Rahmanian; Mohammad Kargar
Journal:  Iran Red Crescent Med J       Date:  2014-12-27       Impact factor: 0.611
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