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Literature DB >> 12215644

Mast cells: a cellular link between autoantibodies and inflammatory arthritis.

David M Lee¹, Daniel S Friend, Michael F Gurish, Christophe Benoist, Diane Mathis, Michael B Brenner.

Abstract

Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.

Entities: Disease Gene Species

Mesh：

Substances：
Autoantibodies

Year: 2002 PMID： 12215644 DOI： 10.1126/science.1073176

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

253 in total

1. Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanism.

Authors: Jun-Xia Wang; Angela M Bair; Sandra L King; Ruslan Shnayder; Ya-Fang Huang; Chi-Chang Shieh; Roy J Soberman; Robert C Fuhlbrigge; Peter A Nigrovic
Journal: Blood Date: 2012-06-01 Impact factor: 22.113

2. Cellular therapies supplement: the role of granulocyte macrophage colony-stimulating factor and dendritic cells in regulatory T-cell homeostasis and expansion.

Authors: Tao Zou; Atsushi Satake; Priti Ojha; Taku Kambayashi
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3. Collagen type II and a thermo-responsive polymer of N-isopropylacrylamide induce arthritis independent of Toll-like receptors: a strong influence by major histocompatibility complex class II and Ncf1 genes.

Authors: Akhilesh Kumar Shakya; Ashok Kumar; Dorota Klaczkowska; Malin Hultqvist; Kristin Hagenow; Rikard Holmdahl; Kutty Selva Nandakumar
Journal: Am J Pathol Date: 2011-09-18 Impact factor: 4.307

Review 4. Antigen-specific T cells in rheumatoid arthritis.

Authors: Sean R Bennett; Michael T Falta; Jerry Bill; Brian L Kotzin
Journal: Curr Rheumatol Rep Date: 2003-08 Impact factor: 4.592

Review 5. Cell biology of osteoimmunology.

Authors: Reinhard Gruber
Journal: Wien Med Wochenschr Date: 2010-08-16

Mast cells: a cellular link between autoantibodies and inflammatory arthritis.

1. Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanism.

2. Cellular therapies supplement: the role of granulocyte macrophage colony-stimulating factor and dendritic cells in regulatory T-cell homeostasis and expansion.

3. Collagen type II and a thermo-responsive polymer of N-isopropylacrylamide induce arthritis independent of Toll-like receptors: a strong influence by major histocompatibility complex class II and Ncf1 genes.

Review 4. Antigen-specific T cells in rheumatoid arthritis.

Review 5. Cell biology of osteoimmunology.

6. New role for mast cells as IL-17-expressing effector cells in established RA.

7. A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway.

8. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.

9. Association Between Mast Cells and Collagen Maturation in Chronic Periodontitis in Humans.

Review 10. Initiation of an autoimmune response: insights from a transgenic model of rheumatoid arthritis.