Immune neutropenia in the neonate.

Immune-mediated neonatal neutropenias include alloimmune neonatal neutropenia, neonatal autoimmune neutropenia, and autoimmune neutropenia of infancy. These disorders have remained somewhat nebulous entities with difficulties persisting in both clinical identification and laboratory confirmation. A review of these disorders is presented, with basic information on the neutrophil antigen systems, pathophysiologic mechanisms, laboratory diagnosis, and therapeutic options.