P Gosse1, J Taillard, J Constans. 1. Service de Cardiologie et Hypertension Artérielle et Service de Médecine Interne et Pathologie Vasculaire, Hôpital Saint-André, 1 rue Jean Burguet, 33075 Bordeaux, France. philippe.gosse@chu-bordeaux.fr
Abstract
UNLABELLED: Patients with systemic sclerosis commonly exhibit increased arterial stiffness, which may be predictive of the overall severity of the disease. The aim of the present study was to check the stability of parameters of arterial stiffness after 1 year in this population. ERAMS is a French multicentric prospective study designed to identify a link between arterial distensibility and outcome in 100 patients with systemic sclerosis. Arterial distensibility was evaluated by 24-h ambulatory monitoring of QKD interval along with blood pressure (BP) and heart rate (HR) (four measurements/hour). The index QKD(100-60), which is linked to aortic distensibility, was calculated automatically. QKD(100-60) is the value of QKD (which depends on pulse wave velocity) for 100 mm Hg sBP and 60 bpm HR. The reproducibility of QKD(100-60) was assessed on the first patients to be followed up for a complete year. So far the 100 patients have been recruited from 14 participating centres and 48 were re-evaluated after 1 year. QKD(100-60) was highly reproducible: 201 +/- 6 vs202 +/- 18 msec, standard deviation of difference = 13 msec. IN CONCLUSION: determination of QKD(100-60) to assess arterial stiffness gives stable results over 1 year in patients with systemic sclerosis.
UNLABELLED: Patients with systemic sclerosis commonly exhibit increased arterial stiffness, which may be predictive of the overall severity of the disease. The aim of the present study was to check the stability of parameters of arterial stiffness after 1 year in this population. ERAMS is a French multicentric prospective study designed to identify a link between arterial distensibility and outcome in 100 patients with systemic sclerosis. Arterial distensibility was evaluated by 24-h ambulatory monitoring of QKD interval along with blood pressure (BP) and heart rate (HR) (four measurements/hour). The index QKD(100-60), which is linked to aortic distensibility, was calculated automatically. QKD(100-60) is the value of QKD (which depends on pulse wave velocity) for 100 mm Hg sBP and 60 bpm HR. The reproducibility of QKD(100-60) was assessed on the first patients to be followed up for a complete year. So far the 100 patients have been recruited from 14 participating centres and 48 were re-evaluated after 1 year. QKD(100-60) was highly reproducible: 201 +/- 6 vs202 +/- 18 msec, standard deviation of difference = 13 msec. IN CONCLUSION: determination of QKD(100-60) to assess arterial stiffness gives stable results over 1 year in patients with systemic sclerosis.
Authors: Alma Cypiene; Aleksandras Laucevicius; Algirdas Venalis; Jolanta Dadoniene; Ligita Ryliskyte; Zaneta Petrulioniene; Milda Kovaite; Jonas Gintautas Journal: Clin Rheumatol Date: 2008-07-25 Impact factor: 2.980
Authors: R T Domsic; C Dezfulian; Al Shoushtari; D Ivanco; E Kenny; C K Kwoh; T A Medsger; H C Champion Journal: Clin Exp Rheumatol Date: 2014-11-05 Impact factor: 4.473