Literature DB >> 12213462

Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.

Junko Ishida1, Hironori Ohtsu, Yoko Tachibana, Yuka Nakanishi, Kenneth F Bastow, Masahiro Nagai, Hui-Kang Wang, Hideji Itokawa, Kuo-Hsiung Lee.   

Abstract

Fifty-eight curcumin analogues were prepared and evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Compound was the most potent analogue against several cell lines, including HOS (bone cancer) and 1A9 (breast cancer), with ED50 values of 0.97 and <0.63 microg/mL, respectively.

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Year:  2002        PMID： 12213462     DOI： 10.1016/s0968-0896(02)00249-3

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  18 in total

1.  Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.

Authors:  Li Lin; Qian Shi; Alexander K Nyarko; Kenneth F Bastow; Chin-Chung Wu; Ching-Yuan Su; Charles C-Y Shih; Kuo-Hsiung Lee
Journal:  J Med Chem       Date:  2006-06-29       Impact factor: 7.446

2.  Facile synthesis of deuterated and [(14) C]labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools.

Authors:  Odaine N Gordon; Leigh A Graham; Claus Schneider
Journal:  J Labelled Comp Radiopharm       Date:  2013-07-23       Impact factor: 1.921

3.  Phenolic 1,3-diketones attenuate lipopolysaccharide-induced inflammatory response by an alternative magnesium-mediated mechanism.

Authors:  Morena Zusso; Giulia Mercanti; Federica Belluti; Rita Maria Concetta Di Martino; Andrea Pagetta; Carla Marinelli; Paola Brun; Eugenio Ragazzi; Rita Lo; Stefano Stifani; Pietro Giusti; Stefano Moro
Journal:  Br J Pharmacol       Date:  2017-03-31       Impact factor: 8.739

4.  Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents.

Authors:  Jin Tatsuzaki; Kenneth F Bastow; Kyoko Nakagawa-Goto; Seiko Nakamura; Hideji Itokawa; Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2006-10       Impact factor: 4.050

5.  The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells.

Authors:  Alexandra M Fajardo; Debra A MacKenzie; Ming Ji; Lorraine M Deck; David L Vander Jagt; Todd A Thompson; Marco Bisoffi
Journal:  Prostate       Date:  2011-07-27       Impact factor: 4.104

6.  Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens.

Authors:  Qian Shi; Koji Wada; Emika Ohkoshi; Li Lin; Rong Huang; Susan L Morris-Natschke; Masuo Goto; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem       Date:  2012-05-15       Impact factor: 3.641

7.  Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.

Authors:  Koji Wada; Jen-Yi Lee; Hsin-Yi Hung; Qian Shi; Li Lin; Yu Zhao; Masuo Goto; Pan-Chyr Yang; Sheng-Chu Kuo; Hui-Wen Chen; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem       Date:  2015-02-13       Impact factor: 3.641

8.  Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents.

Authors:  Nawras Samaan; Qiu Zhong; Jayjoel Fernandez; Guanglin Chen; Ali M Hussain; Shilong Zheng; Guangdi Wang; Qiao-Hong Chen
Journal:  Eur J Med Chem       Date:  2014-01-29       Impact factor: 6.514

Review 9.  Novel agents for the prevention of breast cancer: targeting transcription factors and signal transduction pathways.

Authors:  Qiang Shen; Powel H Brown
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-01       Impact factor: 2.673

10.  Pyridine analogues of curcumin exhibit high activity for inhibiting CWR-22Rv1 human prostate cancer cell growth and androgen receptor activation.

Authors:  Dai-Ying Zhou; Su-Qing Zhao; Zhi-Yun DU; X I Zheng; Kun Zhang
Journal:  Oncol Lett       Date:  2016-05-06       Impact factor: 2.967
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