Literature DB >> 12213311

Cyclic AMP-mediated modulation of epileptiform afterdischarge generation in rat hippocampal slices.

Masato Higashima1, Koji Ohno, Yoshifumi Koshino.   

Abstract

This study assessed the effects of drugs which manipulate the cAMP system on afterdischarges (ADs) induced in the CA1 region of rat hippocampal slices. The adenylate cyclase activator forskolin (50 microM) and the phosphodiesterase inhibitor rolipram (0.1 and 1 microM) enhanced AD generation. These effects were reversed by the cAMP-dependent protein kinase inhibitors H-89 (5 microM) and Rp-cAMPS (100 microM). These findings suggest that AD generation can be modulated through cAMP generation and the subsequent activation of the cAMP-dependent protein kinase. Copyright 2002 Elsevier Science B.V.

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Year:  2002        PMID： 12213311     DOI： 10.1016/s0006-8993(02)02976-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

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