Literature DB >> 12213271

Tyrosine dephosphorylation underlies DHPG-induced LTD.

Peter R Moult1, Rebecca Schnabel, Ian C Kilpatrick, Zafar I Bashir, Graham L Collingridge.   

Abstract

A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 microM lavendustin A or 30 microM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 microM phenyl-arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase.

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Year:  2002        PMID： 12213271     DOI： 10.1016/s0028-3908(02)00110-7

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  16 in total

1.  Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

Authors:  Lingfei Hou; Eric Klann
Journal:  J Neurosci       Date:  2004-07-14       Impact factor: 6.167

2.  Group I mGluRs and long-term depression: potential roles in addiction?

Authors:  Brad A Grueter; Zoé A McElligott; Danny G Winder
Journal:  Mol Neurobiol       Date:  2007-07-27       Impact factor: 5.590

Review 3.  Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease.

Authors:  Christian Lüscher; Kimberly M Huber
Journal:  Neuron       Date:  2010-02-25       Impact factor: 17.173

4.  Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression.

Authors:  Peter R Moult; Sônia A L Corrêa; Graham L Collingridge; Stephen M Fitzjohn; Zafar I Bashir
Journal:  J Physiol       Date:  2008-03-20       Impact factor: 5.182

Review 5.  Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms.

Authors:  Clare M Gladding; Stephen M Fitzjohn; Elek Molnár
Journal:  Pharmacol Rev       Date:  2009-11-19       Impact factor: 25.468

6.  Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices.

Authors:  Gerhard Rammes; Mary Palmer; Matthias Eder; Hans-Ulrich Dodt; Walter Zieglgänsberger; Graham L Collingridge
Journal:  J Physiol       Date:  2003-01-15       Impact factor: 5.182

7.  Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K(+) channels.

Authors:  Anne-Marie White; Risto A Kylänpää; Louisa A Christie; Simon J McIntosh; Andrew J Irving; Bettina Platt
Journal:  Br J Pharmacol       Date:  2003-11-17       Impact factor: 8.739

8.  Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.

Authors:  Sonia Piccinin; Carlo Cinque; Laura Calò; Gemma Molinaro; Giuseppe Battaglia; Laura Maggi; Ferdinando Nicoletti; Daniela Melchiorri; Fabrizio Eusebi; Peter V Massey; Zafar I Bashir
Journal:  J Neurosci       Date:  2010-02-24       Impact factor: 6.167

9.  Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs.

Authors:  Thomas M Sanderson; Graham L Collingridge; Stephen M Fitzjohn
Journal:  Mol Brain       Date:  2011-07-27       Impact factor: 4.041

10.  Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression.

Authors:  Peter R Moult; Clare M Gladding; Thomas M Sanderson; Stephen M Fitzjohn; Zafar I Bashir; Elek Molnar; Graham L Collingridge
Journal:  J Neurosci       Date:  2006-03-01       Impact factor: 6.167
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