| Literature DB >> 12213052 |
Zhihua Sui1, Jihua Guan, Mark J Macielag, Weiqin Jiang, Suying Zhang, Yuhong Qiu, Patricia Kraft, Sheela Bhattacharjee, T Matthew John, Donna Haynes-Johnson, Joanna Clancy.
Abstract
A series of N-pyrimidinylpyrroloquinolones were discovered as extremely potent and selective PDE5 inhibitors. Representative compounds demonstrated in vivo efficacy in dog erectile dysfunction models and are orally bioavailable.Entities:
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Year: 2002 PMID： 12213052 DOI： 10.1021/jm025545d
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446