Literature DB >> 12212784

Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease.

Paul E Bendheim1, Burkhard Poeggeler, Eyal Neria, Vivi Ziv, Miguel A Pappolla, Daniel G Chain.   

Abstract

The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.

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Year:  2002        PMID： 12212784     DOI： 10.1007/s12031-002-0036-0

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  30 in total

1.  Comparison of the protective effect of melatonin with other antioxidants in the hamster kidney model of estradiol-induced DNA damage.

Authors:  M Karbownik; R J Reiter; J Cabrera; J J Garcia
Journal:  Mutat Res       Date:  2001-03-01       Impact factor: 2.433

2.  Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

Authors:  M P Lambert; A K Barlow; B A Chromy; C Edwards; R Freed; M Liosatos; T E Morgan; I Rozovsky; B Trommer; K L Viola; P Wals; C Zhang; C E Finch; G A Krafft; W L Klein
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

3.  The origin of indoleacetic acid and indolepropionic acid in rat and human cerebrospinal fluid.

Authors:  S N Young; G M Anderson; S Gauthier; W C Purdy
Journal:  J Neurochem       Date:  1980-05       Impact factor: 5.372

Review 4.  Oxidants, antioxidants, and the degenerative diseases of aging.

Authors:  B N Ames; M K Shigenaga; T M Hagen
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

5.  SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein.

Authors:  C Iadecola; F Zhang; K Niwa; C Eckman; S K Turner; E Fischer; S Younkin; D R Borchelt; K K Hsiao; G A Carlson
Journal:  Nat Neurosci       Date:  1999-02       Impact factor: 24.884

Review 6.  Antioxidant therapy in neurologic disease.

Authors:  N Delanty; M A Dichter
Journal:  Arch Neurol       Date:  2000-09

7.  Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: protection by antioxidants.

Authors:  C Pereira; M S Santos; C Oliveira
Journal:  Neurobiol Dis       Date:  1999-06       Impact factor: 5.996

Review 8.  Antioxidants, oxidative stress, and degenerative neurological disorders.

Authors:  R A Floyd
Journal:  Proc Soc Exp Biol Med       Date:  1999-12

9.  Indole-3-propionate: a potent hydroxyl radical scavenger in rat brain.

Authors:  B Poeggeler; M A Pappolla; R Hardeland; A Rassoulpour; P S Hodgkins; P Guidetti; R Schwarcz
Journal:  Brain Res       Date:  1999-01-09       Impact factor: 3.252

10.  Vitamin E protects nerve cells from amyloid beta protein toxicity.

Authors:  C Behl; J Davis; G M Cole; D Schubert
Journal:  Biochem Biophys Res Commun       Date:  1992-07-31       Impact factor: 3.575
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  30 in total

Review 1.  Emotional triggering of cardiac dysfunction: the present and future.

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Journal:  Curr Cardiol Rep       Date:  2015-10       Impact factor: 2.931

2.  Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation.

Authors:  Xun Cheng; Richard B van Breemen
Journal:  Anal Chem       Date:  2005-11-01       Impact factor: 6.986

3.  Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.

Authors:  William R Wikoff; Andrew T Anfora; Jun Liu; Peter G Schultz; Scott A Lesley; Eric C Peters; Gary Siuzdak
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-20       Impact factor: 11.205

4.  Indole Propionic Acid: a Small Molecule Links between Gut Microbiota and Tuberculosis.

Authors:  Stefan H E Kaufmann
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

5.  Asymmetric hydrovinylation of vinylindoles. A facile route to cyclopenta[g]indole natural products (+)-cis-trikentrin A and (+)-cis-trikentrin B.

Authors:  Wang Liu; Hwan Jung Lim; T V RajanBabu
Journal:  J Am Chem Soc       Date:  2012-03-13       Impact factor: 15.419

6.  Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs.

Authors:  Hao Li; Harmit S Ranhotra; Sridhar Mani; Zdeněk Dvořák; Harry Sokol; Rolf Müller
Journal:  Drug Discov Today       Date:  2020-06-17       Impact factor: 7.851

7.  Ammonia generation by tryptophan synthase drives a key genetic difference between genital and ocular Chlamydia trachomatis isolates.

Authors:  Shardulendra P Sherchand; Ashok Aiyar
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-16       Impact factor: 11.205

8.  Metabolomics analysis reveals insights into biochemical mechanisms of mental stress-induced left ventricular dysfunction.

Authors:  Stephen H Boyle; Wayne R Matson; Eric J Velazquez; Zainab Samad; Redford B Williams; Swati Sharma; Beena Thomas; Jennifer L Wilson; Christopher O'Connor; Wei Jiang
Journal:  Metabolomics       Date:  2015-06-01       Impact factor: 4.290

Review 9.  Gut microbiota and chronic kidney disease: evidences and mechanisms that mediate a new communication in the gastrointestinal-renal axis.

Authors:  Natalia Lucía Rukavina Mikusic; Nicolás Martín Kouyoumdzian; Marcelo Roberto Choi
Journal:  Pflugers Arch       Date:  2020-02-17       Impact factor: 3.657

10.  A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice.

Authors:  Ibrahim Yusufu; Kehong Ding; Kathryn Smith; Umesh D Wankhade; Bikash Sahay; G Taylor Patterson; Rafal Pacholczyk; Satish Adusumilli; Mark W Hamrick; William D Hill; Carlos M Isales; Sadanand Fulzele
Journal:  Int J Mol Sci       Date:  2021-05-08       Impact factor: 5.923
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