H Yu1, J Hong, D Wu. 1. Basic Medical School of Hubei Medical University, Wuhan 430071.
Abstract
OBJECTIVE: To investigate the effect of sodium ferulate on the proliferation and lipid peroxidation of aortic smooth muscle cells(SMC). METHOD: Using experimental models of proliferation of cultured rabbit aortic SMC induced by oxidized-low density lipoprotein, the level of lipoperoxide(LPO) was determined by thiobarbituric acid reactive substance(TBARS) method and 3H-thymidine(3H-TdR) incorporation was used to observe DNA synthesis. RESULTS: SF markedly reduced the increase of medium LPO and inhibited the 3H-TdR incorporation in a dose-dependent manner. CONCLUSION: SF can inhibit the proliferation of SMC. The inhibitory effect may be related to the inhibition of lipid peroxidation.
OBJECTIVE: To investigate the effect of sodium ferulate on the proliferation and lipid peroxidation of aortic smooth muscle cells(SMC). METHOD: Using experimental models of proliferation of cultured rabbit aortic SMC induced by oxidized-low density lipoprotein, the level of lipoperoxide(LPO) was determined by thiobarbituric acid reactive substance(TBARS) method and 3H-thymidine(3H-TdR) incorporation was used to observe DNA synthesis. RESULTS: SF markedly reduced the increase of medium LPO and inhibited the 3H-TdR incorporation in a dose-dependent manner. CONCLUSION: SF can inhibit the proliferation of SMC. The inhibitory effect may be related to the inhibition of lipid peroxidation.