Literature DB >> 12211414

ART-123 Asahi Kasei.

Sascha Khorchidi1, Ruediger Bantleon, Rainer Kehlbach, Gunnar Tepe, Jakub Wiskirchen, Stephan H Duda.   

Abstract

Asahi Kasei is developing a recombinant thrombomodulin (ART-123), a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism [169907]. By September 2000, it had entered phase III trials [383525]. A patent, US-05916874, claiming a method for treating liver injury and whose composition comprises a thrombomodulin, was published in 1999 by the company.

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Year:  2002        PMID: 12211414

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN: 1472-4472


  3 in total

Review 1.  Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome.

Authors:  Sara C Sebag; Julie A Bastarache; Lorraine B Ware
Journal:  Curr Pharm Biotechnol       Date:  2011-09       Impact factor: 2.837

2.  Recombinant thrombomodulin protects against LPS-induced acute respiratory distress syndrome via preservation of pulmonary endothelial glycocalyx.

Authors:  Kodai Suzuki; Hideshi Okada; Genzou Takemura; Chihiro Takada; Hiroyuki Tomita; Hirohisa Yano; Isamu Muraki; Ryogen Zaikokuji; Ayumi Kuroda; Hirotsugu Fukuda; Ayane Nishio; Shigeo Takashima; Akio Suzuki; Nagisa Miyazaki; Tetsuya Fukuta; Noriaki Yamada; Takatomo Watanabe; Tomoaki Doi; Takahiro Yoshida; Keisuke Kumada; Hiroaki Ushikoshi; Shozo Yoshida; Shinji Ogura
Journal:  Br J Pharmacol       Date:  2020-07-14       Impact factor: 8.739

Review 3.  Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection.

Authors:  Hideshi Okada; Shozo Yoshida; Akira Hara; Shinji Ogura; Hiroyuki Tomita
Journal:  Microcirculation       Date:  2020-08-30       Impact factor: 2.679

  3 in total

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