Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.

Literature DB >> 12210791

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.

John E Duda¹, Benoit I Giasson, Meghann E Mabon, Virginia M-Y Lee, John Q Trojanowski.

Abstract

Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12210791 DOI： 10.1002/ana.10279

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

Keyword Cloud
Cited

118 in total

1. alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases.

Authors: Nigel J Cairns; Kunihiro Uryu; Eileen H Bigio; Ian R A Mackenzie; Marla Gearing; Charles Duyckaerts; Hideaki Yokoo; Yoichi Nakazato; Evelyn Jaros; Robert H Perry; Steven E Arnold; Virginia M-Y Lee; John Q Trojanowski
Journal: Acta Neuropathol Date: 2004-05-28 Impact factor: 17.088

Review 2. Axon degeneration in Parkinson's disease.

Authors: Robert E Burke; Karen O'Malley
Journal: Exp Neurol Date: 2012-01-18 Impact factor: 5.330

3. Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.

Authors: Steven E Arnold; Edward B Lee; Paul J Moberg; Lauren Stutzbach; Hala Kazi; Li-Ying Han; Virginia M Y Lee; John Q Trojanowski
Journal: Ann Neurol Date: 2010-04 Impact factor: 10.422

4. Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain.

Authors: Lauren G Friedman; M Lenard Lachenmayer; Jing Wang; Liqiang He; Shibu M Poulose; Masaaki Komatsu; Gay R Holstein; Zhenyu Yue
Journal: J Neurosci Date: 2012-05-30 Impact factor: 6.167

Review 5. Dynamic structural flexibility of α-synuclein.

Authors: Danielle E Mor; Scott E Ugras; Malcolm J Daniels; Harry Ischiropoulos
Journal: Neurobiol Dis Date: 2015-12-31 Impact factor: 5.996

6. Neuropathologic substrates of Parkinson disease dementia.

Authors: David J Irwin; Matthew T White; Jon B Toledo; Sharon X Xie; John L Robinson; Vivianna Van Deerlin; Virginia M-Y Lee; James B Leverenz; Thomas J Montine; John E Duda; Howard I Hurtig; John Q Trojanowski
Journal: Ann Neurol Date: 2012-10-04 Impact factor: 10.422

7. GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.

Authors: Debby Tsuang; James B Leverenz; Oscar L Lopez; Ronald L Hamilton; David A Bennett; Julie A Schneider; Aron S Buchman; Eric B Larson; Paul K Crane; Jeffrey A Kaye; Patricia Kramer; Randy Woltjer; Walter Kukull; Peter T Nelson; Gregory A Jicha; Janna H Neltner; Doug Galasko; Eliezer Masliah; John Q Trojanowski; Gerard D Schellenberg; Dora Yearout; Haley Huston; Allison Fritts-Penniman; Ignacio F Mata; Jia Y Wan; Karen L Edwards; Thomas J Montine; Cyrus P Zabetian
Journal: Neurology Date: 2012-10-03 Impact factor: 9.910