| Literature DB >> 12210185 |
Ludmila Alaverdian1, Sinok Alaverdian, Olga Bilenko, Iouri Bogdanov, Elena Filippova, Dmitry Gavrilov, Boris Gorbovitski, Michael Gouzman, Georgy Gudkov, Sergey Domratchev, Olga Kosobokova, Nadia Lifshitz, Serge Luryi, Victor Ruskovoloshin, Andrew Stepoukhovitch, Marina Tcherevishnick, Georgy Tyshko, Vera Gorfinkel.
Abstract
We have developed a family of high-performance capillary DNA sequencing instruments based on a novel multicolor fluorescent detection technology. This technology is based on two technical innovations: the multilaser excitation of fluorescence of labeled DNA fragments and the "color-blind" single-photon detection of modulated fluorescence. Our machines employ modern digital and broadband techniques that are essential for achieving superior instrument performance. We discuss the design and testing results for several versions of the automated single lane DNA sequencers, as well as our approach to scaling up to multilane instruments.Mesh：
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Year: 2002 PMID： 12210185 DOI： 10.1002/1522-2683(200208)23:16<2804::AID-ELPS2804>3.0.CO;2-9
Source DB: PubMed Journal: Electrophoresis ISSN： 0173-0835 Impact factor: 3.535