Literature DB >> 12209150

Protein tyrosine phosphatase 1B inhibitors for diabetes.

Theodore O Johnson1, Jacques Ermolieff, Michael R Jirousek.   

Abstract

Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need for new agents to treat these disease states. Resistance to the hormones insulin and leptin are hallmarks of both type 2 diabetes and obesity. Drugs that can ameliorate this resistance should be effective in treating type 2 diabetes and possibly obesity. Protein tyrosine phosphatase 1B (PTP1B) is thought to function as a negative regulator of insulin and leptin signal transduction. This article reviews PTP1B as a novel target for type 2 diabetes, and looks at the challenges in developing small-molecule inhibitors of this phosphatase.

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Year:  2002        PMID： 12209150     DOI： 10.1038/nrd895

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  116 in total

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Review 3.  Transgenic mouse models resistant to diet-induced metabolic disease: is energy balance the key?

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9.  A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models.

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Journal:  J Biol Chem       Date:  2017-12-07       Impact factor: 5.157

Review 10.  Novel and emerging diabetes mellitus drug therapies for the type 2 diabetes patient.

Authors:  Charmaine D Rochester; Oluwaranti Akiyode
Journal:  World J Diabetes       Date:  2014-06-15
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