Literature DB >> 12209126

Mixed-lineage kinase control of JNK and p38 MAPK pathways.

Kathleen A Gallo1, Gary L Johnson.   

Abstract

Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.

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Year:  2002        PMID： 12209126     DOI： 10.1038/nrm906

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  204 in total

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Review 3.  Ras and Rap signaling in synaptic plasticity and mental disorders.

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4.  Effects of mutant huntingtin on mGluR5-mediated dual signaling pathways: implications for therapeutic interventions.

Authors:  Shan-Shan Huang; Jun He; Dong-Ming Zhao; Xiao-Yuan Xu; Hui-Ping Tan; He Li
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5.  Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons.

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6.  Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.

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7.  Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation.

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Journal:  J Biol Chem       Date:  2008-12-11       Impact factor: 5.157

8.  Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

Authors:  Val S Goodfellow; Colin J Loweth; Satheesh B Ravula; Torsten Wiemann; Thong Nguyen; Yang Xu; Daniel E Todd; David Sheppard; Scott Pollack; Oksana Polesskaya; Daniel F Marker; Stephen Dewhurst; Harris A Gelbard
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9.  The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.

Authors:  Kota Fujiki; Tomoaki Mizuno; Naoki Hisamoto; Kunihiro Matsumoto
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Review 10.  Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: relevance to oxidative stress and neuroinflammation in Parkinson's disease.

Authors:  Anumantha Kanthasamy; Huajun Jin; Suneet Mehrotra; Rajakishore Mishra; Arthi Kanthasamy; Ajay Rana
Journal:  Neurotoxicology       Date:  2009-12-11       Impact factor: 4.294
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