| Literature DB >> 12207689 |
Sergey V Slepenkov1, Stephan N Witt.
Abstract
We discuss recent experiments that have illuminated individual steps in the reaction cycle of the Escherichia coli Hsp70 molecular chaperone DnaK. Using this new information, we compare two distinctly different global mechanisms of action--holding versus unfolding--and argue that the available evidence suggests that DnaK is an unfoldase.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12207689 DOI： 10.1046/j.1365-2958.2002.03093.x
Source DB: PubMed Journal: Mol Microbiol ISSN： 0950-382X Impact factor: 3.501