Literature DB >> 12207089

From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.

Peter J Ratcliffe1.   

Abstract

The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxylation of specific prolyl and asparinyl residues in the alpha subunit of HIF by a series of non-haem iron-dependent dioxygenases has been defined as a novel mechanism of protein modification that transduces the oxygen-sensitive signal. Copyright 2002 S. Karger AG, Basel

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Year:  2002        PMID： 12207089     DOI： 10.1159/000065201

Source DB:  PubMed          Journal:  Blood Purif        ISSN： 0253-5068            Impact factor:   2.614


  13 in total

1.  Illicit organogenesis: Methods and substances of doping and manipulation.

Authors:  Mario Thevis; Wilhelm Schänzer
Journal:  Organogenesis       Date:  2008-10       Impact factor: 2.500

2.  Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation.

Authors:  Oleksandr H Minchenko; Tsutomu Ogura; Iryna L Opentanova; Dmytro O Minchenko; Hiroyasu Esumi
Journal:  Mol Cell Biochem       Date:  2005-12       Impact factor: 3.396

Review 3.  Heart failure and kidney dysfunction: epidemiology, mechanisms and management.

Authors:  Joerg C Schefold; Gerasimos Filippatos; Gerd Hasenfuss; Stefan D Anker; Stephan von Haehling
Journal:  Nat Rev Nephrol       Date:  2016-08-30       Impact factor: 28.314

4.  Gas phase reaction of substituted isoquinolines to carboxylic acids in ion trap and triple quadrupole mass spectrometers after electrospray ionization and collision-induced dissociation.

Authors:  Mario Thevis; Maxie Kohler; Nils Schlörer; Wilhelm Schänzer
Journal:  J Am Soc Mass Spectrom       Date:  2007-11-09       Impact factor: 3.109

5.  Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Authors:  David E Lancaster; Luke A McNeill; Michael A McDonough; Robin T Aplin; Kirsty S Hewitson; Christopher W Pugh; Peter J Ratcliffe; Christopher J Schofield
Journal:  Biochem J       Date:  2004-11-01       Impact factor: 3.857

6.  Nutrient deprivation-related OXPHOS/glycolysis interconversion via HIF-1α/C-MYC pathway in U251 cells.

Authors:  Zhongjian Liu; Yang Sun; Shirui Tan; Liang Liu; Suqiong Hu; Hongyu Huo; Meizhang Li; Qinghua Cui; Min Yu
Journal:  Tumour Biol       Date:  2015-12-08

7.  Erythropoietin in bone homeostasis-Implications for efficacious anemia therapy.

Authors:  Katrina M Lappin; Ken I Mills; Terence R Lappin
Journal:  Stem Cells Transl Med       Date:  2021-01-21       Impact factor: 6.940

8.  Association between HIF1A P582S and A588T polymorphisms and the risk of urinary cancers: a meta-analysis.

Authors:  Dawei Li; Jikai Liu; Wenhua Zhang; Juchao Ren; Lei Yan; Hainan Liu; Zhonghua Xu
Journal:  PLoS One       Date:  2013-05-27       Impact factor: 3.240

9.  Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection.

Authors:  Christopher H Woelk; Jin X Zhang; Lorraine Walls; Suganya Viriyakosol; Akul Singhania; Theo N Kirkland; Joshua Fierer
Journal:  BMC Microbiol       Date:  2012-09-24       Impact factor: 3.605

10.  PFKFB4 Overexpression Facilitates Proliferation by Promoting the G1/S Transition and Is Associated with a Poor Prognosis in Triple-Negative Breast Cancer.

Authors:  Yu-Chen Cai; Hang Yang; Hong-Bo Shan; Hui-Fang Su; Wen-Qi Jiang; Yan-Xia Shi
Journal:  Dis Markers       Date:  2021-06-09       Impact factor: 3.434
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