[Effect of Boschniakia rossica extract on antioxidative activities in rat hepatic preneoplasia induced by diethylnitrosamine].

OBJECTIVE: To study the antioxidative effect of aqueous fraction of Boschniakia rossica(BR) extracted with methanol and fractionated with dichloromethane and water.
METHOD: Serum activities of superoxide dismutase(SOD), malondialdehyde(MDA), glutathione peroxidase (GSH-PX) and glutathione S-transferase (GST) were investigated in rat with preneoplasia induced by Solt-Farber protocol under administration with BR extract for 6 weeks. RESULT: Serum activities of SOD and GSH-PX rose again in rats administered with BR extract, and the increase of GST activity and content of MDA due to hepatic preneoplasia was decreased by the extract of BR, thus the pathological changes of tissues and cells can be reduced.
CONCLUSION: BR extract has antioxidative effect which may be a part of the antitumor mechanism of B. rossica.