PURPOSE: To determine whether automatic and manual measurements of hippocampal volume differences on MRI between normal aging, cognitive impairment (CI), and Alzheimer's disease (AD) yield similar results. MATERIALS AND METHODS: Reliability was determined for an automatic and a manual method on nine volunteers (22-83 years old) who underwent MRI twice in 1 day. Hippocampal volumes of 20 cognitively normal subjects (mean age 74.0 +/- 6.2 years) and age-matched patients (20 CI and 20 AD) were compared. RESULTS: The intraclass correlation for automatic calculations of hippocampal volume was 0.94; for manual tracing it was 0.99. Volume differences between cognitively normal, CI, and AD subjects from the automatic and manual methods were similar. CONCLUSION: Because the automatic calculations were faster and less susceptible to rater bias than manual tracing, this automated method is expected to be very useful for analyzing hippocampal changes in studies of aging and dementia. Copyright 2002 Wiley-Liss, Inc.
PURPOSE: To determine whether automatic and manual measurements of hippocampal volume differences on MRI between normal aging, cognitive impairment (CI), and Alzheimer's disease (AD) yield similar results. MATERIALS AND METHODS: Reliability was determined for an automatic and a manual method on nine volunteers (22-83 years old) who underwent MRI twice in 1 day. Hippocampal volumes of 20 cognitively normal subjects (mean age 74.0 +/- 6.2 years) and age-matched patients (20 CI and 20 AD) were compared. RESULTS: The intraclass correlation for automatic calculations of hippocampal volume was 0.94; for manual tracing it was 0.99. Volume differences between cognitively normal, CI, and AD subjects from the automatic and manual methods were similar. CONCLUSION: Because the automatic calculations were faster and less susceptible to rater bias than manual tracing, this automated method is expected to be very useful for analyzing hippocampal changes in studies of aging and dementia. Copyright 2002 Wiley-Liss, Inc.
Authors: C R Jack; R C Petersen; Y C Xu; S C Waring; P C O'Brien; E G Tangalos; G E Smith; R J Ivnik; E Kokmen Journal: Neurology Date: 1997-09 Impact factor: 9.910
Authors: A T Du; N Schuff; D Amend; M P Laakso; Y Y Hsu; W J Jagust; K Yaffe; J H Kramer; B Reed; D Norman; H C Chui; M W Weiner Journal: J Neurol Neurosurg Psychiatry Date: 2001-10 Impact factor: 10.154
Authors: J G Csernansky; L Wang; S Joshi; J P Miller; M Gado; D Kido; D McKeel; J C Morris; M I Miller Journal: Neurology Date: 2000-12-12 Impact factor: 9.910
Authors: P M Thompson; M S Mega; R P Woods; C I Zoumalan; C J Lindshield; R E Blanton; J Moussai; C J Holmes; J L Cummings; A W Toga Journal: Cereb Cortex Date: 2001-01 Impact factor: 5.357
Authors: G Fein; V Di Sclafani; J Tanabe; V Cardenas; M W Weiner; W J Jagust; B R Reed; D Norman; N Schuff; L Kusdra; T Greenfield; H Chui Journal: Neurology Date: 2000-12-12 Impact factor: 9.910
Authors: J Mazziotta; A Toga; A Evans; P Fox; J Lancaster; K Zilles; R Woods; T Paus; G Simpson; B Pike; C Holmes; L Collins; P Thompson; D MacDonald; M Iacoboni; T Schormann; K Amunts; N Palomero-Gallagher; S Geyer; L Parsons; K Narr; N Kabani; G Le Goualher; D Boomsma; T Cannon; R Kawashima; B Mazoyer Journal: Philos Trans R Soc Lond B Biol Sci Date: 2001-08-29 Impact factor: 6.237
Authors: Brigitte A Apfel; Jessica Ross; Jennifer Hlavin; Dieter J Meyerhoff; Thomas J Metzler; Charles R Marmar; Michael W Weiner; Norbert Schuff; Thomas C Neylan Journal: Biol Psychiatry Date: 2010-11-20 Impact factor: 13.382
Authors: Joel H Kramer; Norbert Schuff; Bruce R Reed; Dan Mungas; An-Tao Du; Howard J Rosen; William J Jagust; Bruce L Miller; Michael W Weiner; Helena C Chui Journal: J Int Neuropsychol Soc Date: 2004-07 Impact factor: 2.892
Authors: D Mungas; D Harvey; B R Reed; W J Jagust; C DeCarli; L Beckett; W J Mack; J H Kramer; M W Weiner; N Schuff; H C Chui Journal: Neurology Date: 2005-08-23 Impact factor: 9.910
Authors: Paul A Yushkevich; Brian B Avants; Sandhitsu R Das; John Pluta; Murat Altinay; Caryne Craige Journal: Neuroimage Date: 2009-12-31 Impact factor: 6.556