| Literature DB >> 12204478 |
Ocal Berkan1, Bülent Saraç, Rahime Simşek, Sahin Yildirim, Yusuf Sarioğlu, Cihat Safak.
Abstract
In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11>pinacidil>7>2>8>3>1>4>10>6>9>5>12.Entities:
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Year: 2002 PMID： 12204478 DOI： 10.1016/s0223-5234(02)01374-0
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514