Literature DB >> 12204

The systemic use of procaine in the treatment of the elderly: a review.

A Ostfeld, C M Smith, B A Stotsky.   

Abstract

This article is a review and evaluation of the world literature on the systemic use of procaine in the treatment of the aging process and the common chronic diseases of later life. Included are data from 285 articles and books, describing treatment in more than 100,000 patients in the past 25 years. Except for a possible antidepressant effect, there is no convincing evidence that procaine (or Gerovital, of which procaine is the major component) has any value in the treatment of disease in older patients. If procaine has an antidepressant effect, there is some likelihood that this accounts for the reports of decreased complaints referable to the musculoskeletal, cardiovascular, endocrine sexual, gastrointestinal and respiratory systems.

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Year:  1977        PMID: 12204     DOI: 10.1111/j.1532-5415.1977.tb00917.x

Source DB:  PubMed          Journal:  J Am Geriatr Soc        ISSN: 0002-8614            Impact factor:   5.562


  4 in total

Review 1.  Diagnostic and pharmacological approaches in Alzheimer's disease.

Authors:  C Hermann; R G Stern; M F Losonzcy; S Jaff; M Davidson
Journal:  Drugs Aging       Date:  1991-03       Impact factor: 3.923

2.  Antinociception induced by systemic administration of local anaesthetics depends on a central cholinergic mechanism.

Authors:  A Bartolini; A Galli; C Ghelardini; A Giotti; M Malcangio; P Malmberg-Aiello; P L Zucchi
Journal:  Br J Pharmacol       Date:  1987-12       Impact factor: 8.739

3.  The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals.

Authors:  Anca Ungurianu; Denisa Margina; Claudia Borsa; Cristina Ionescu; Gudrun von Scheven; Lucie Oziol; Philippe Faure; Yves Artur; Alexander Bürkle; Daniela Gradinaru; Maria Moreno-Villanueva
Journal:  Oxid Med Cell Longev       Date:  2020-06-24       Impact factor: 6.543

Review 4.  Procaine-The Controversial Geroprotector Candidate: New Insights Regarding Its Molecular and Cellular Effects.

Authors:  Daniela Gradinaru; Anca Ungurianu; Denisa Margina; Maria Moreno-Villanueva; Alexander Bürkle
Journal:  Oxid Med Cell Longev       Date:  2021-07-31       Impact factor: 6.543

  4 in total

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