| Literature DB >> 12203636 |
Abstract
By a sequence comprising asymmetric hydroboration, boron-zinc exchange, and transmetalation with copper, allylations, alkynylations, and allenylations of unsaturated ketals or acetals can be performed with good enantioselectivities (see scheme, (-)-IpcBH2 =(-)-isopinocampheylborane, TMS=Me3 Si). The products correspond to a formal Michael addition with inversion of polarity.Entities:
Keywords: Michael addition; asymmetric synthesis; hydroboration; umpolung; zinc
Year: 2001 PMID： 12203636 DOI： 10.1002/1521-3773(20010817)40:16<3022::AID-ANIE3022>3.0.CO;2-W
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336